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. Author manuscript; available in PMC: 2020 Jan 13.
Published in final edited form as: Eur J Med Chem. 2014 Nov 13;90:332–341. doi: 10.1016/j.ejmech.2014.11.025

Scheme 2.

Scheme 2.

Synthesis of the unsaturated-diyne derivative. Reagents and conditions: (a) NBS, AgNO3, Acetone, r.t.; (b) CrO3, H2SO4, H2O, Acetone, −5 °C; (c) CuCl, 30% n-BuNH2, NH2OHHCl, Et2O, r.t.