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General scheme for alkylation. Reagents and conditions: (a) i) LiHMDS, THF, R2CHO, −78 °C. ii) MsCl, CH2Cl2, DBU; (b) BCl3, CH2Cl2, −78 °C or CAN, CH3CN/H2O; (c) TBAF, THF; (d) EDC, DMAP, CH2Cl2, r.t.; (e) TEA, DMAP, CH2Cl2, r.t.; (f) BCl3, CH2Cl2, −78 °C or CAN, CH3CN/H2O.
