Table 1. Characteristics of the included two-arm studies.
| Study Nr | Study (author) | Year | Ref. | ILD | Biopsy-proven | ILD board approved | Idiopathic forms (secondary cause excluded) | Sample size | Age (mean) | age (mean) standard deviation | Male (n) | Smoking (ever and past smokers; n) | Total disease extent (mean % of Lung volume) | GGO (y/n) | GGO extent (mean % of Lung volume) | Honeycombing (y/n) | Honeycombing extent (mean % of Lung volume) | Consolidation (y/n) | Consolidation extent (mean % of Lung volume) | Reticulation (y/n) | Reticulation extent (mean % of Lung volume) | Predominant GGO: GGO>(R+H) | Predominat reticulation: (R+H)>GGO | H: H and/or R > G | Subpleural sparing (y/n) | Emphysema (y/n) | Emphysema extent (mean % of Lung volume) | Mosaic GGO (y/n) | Peripheral predominance (outer 1/3, n) | Central predominance/perbronchial (inner 2/3, n) | Diffuse axial distribution (n) | Upper lung predominant distribution (n) | Lower lung predominant (below carina, n) | Diffuse distribution: both upper and lower lungs (n) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Kondoh et al | 2005 | [23] | NSIP | 1 | 1 | 12 | 55.3 | 6.6 | 4 | 4 | |||||||||||||||||||||||
| UIP | 1 | 1 | 27 | 56.0 | 10.9 | 20 | 20 | |||||||||||||||||||||||||||
| 2 | Sumikawa et al | 2014 | [24] | NSIP | 1 | 1 | 39 | 57.7 | 10.7 | 24 | 22 | 35.9 | 19.8 | 0.2 | 5.7 | 12 | 1.8 | 17 | 16 | 6 | ||||||||||||||
| UIP | 1 | 1 | 1 | 75 | 62.9 | 8.2 | 55 | 46 | 39.0 | 18.4 | 1.5 | 4.4 | 7 | 1.7 | 59 | 11 | 5 | |||||||||||||||||
| 3 | Aaløkken et al | 2012 | [25] | NSIP | 1 | 1 | 1 | 28 | 22.9 | 5.6 | 12.5 | 1.6 | 7.3 | |||||||||||||||||||||
| UIP | 1 | 1 | 1 | 36 | 24.5 | 1.4 | 30.3 | 1.1 | 6.8 | |||||||||||||||||||||||||
| 4 | Sumikawa et al | 2012 | [26] | NSIP | 1 | 1 | 1 | 10 | 5 | 1 | 4 | 1 | 4 | 5 | 1 | 8 | ||||||||||||||||||
| UIP | 1 | 1 | 1 | 25 | 8 | 14 | 4 | 12 | 22 | 2 | 1 | 21 | ||||||||||||||||||||||
| 5 | Akira | 2009 | [27] | NSIP | 1 | 1 | 54 | 59.2 | 9.5 | 29 | 15.8 | 8.3 | 0.4 | 2.7 | 8 | 25 | 0 | 22 | 3 | 7.3 | 20 | |||||||||||||
| UIP | 1 | 1 | 42 | 61.4 | 8.7 | 31 | 17.8 | 5.6 | 3.0 | 1.1 | 2 | 39 | 6 | 0 | 7 | 9.7 | 2 | |||||||||||||||||
| 6 | Silva et al | 2008 | [28] | NSIP | 1 | 25 | 54.1 | 12.9 | 6 | 38.8 | 25 | 8 | 1 | 25 | 16 | 9 | 18 | 7 | 0 | 23 | 2 | |||||||||||||
| UIP | 1 | 1 | 23 | 62.0 | 6.9 | 17 | 22.6 | 23 | 16 | 0 | 23 | 1 | 10 | 18 | 5 | 0 | 19 | 4 | ||||||||||||||||
| 7 | Sumikawa et al | 2006 | [29] | NSIP | 1 | 1 | 32 | 25.5 | 0.5 | 10.5 | 2.0 | 12 | 0 | 30 | 2 | |||||||||||||||||||
| UIP | 1 | 1 | 20 | 20.0 | 4.0 | 6.0 | 6.0 | 15 | 0 | 20 | 0 | |||||||||||||||||||||||
| 8 | Tsubamoto et al | 2005 | [30] | NSIP | 1 | 1 | 36 | 31.3 | 1.7 | 10.8 | 12 | 22 | 2 | 1 | 32 | 3 | ||||||||||||||||||
| UIP | 1 | 1 | 11 | 17.6 | 21.0 | 3.3 | 10 | 1 | 0 | 0 | 11 | 0 | ||||||||||||||||||||||
| 9 | Jeong et al | 2005 | [31] | NSIP | 1 | 25 | 33.0 | 20.0 | 2.0 | 3.0 | 9.0 | |||||||||||||||||||||||
| UIP | 1 | 70 | 35.0 | 18.0 | 7.5 | 0.5 | 9.5 | |||||||||||||||||||||||||||
| 10 | Elliot et al | 2005 | [32] | NSIP | 1 | 25 | 50.0 | 12.0 | 8 | 1 | 19 | 0 | 6 | |||||||||||||||||||||
| UIP | 1 | 1 | 22 | 58.0 | 11.0 | 17 | 9 | 21 | 0 | 1 | ||||||||||||||||||||||||
| 11 | MacDonald et al | 2001 | [33] | NSIP | 1 | 1 | 21 | 54.3 | 12 | 37.1 | 17.6 | 0.0 | 6 | 6.25 | ||||||||||||||||||||
| UIP | 1 | 1 | 32 | 53.1 | 22 | 44.0 | 11.7 | 0.0 | 2.75 | 18.25 | ||||||||||||||||||||||||
| 12 | Nagai et al | 1998 | [34] | NSIP | 1 | 1 | 31 | 15 | 18 | 26 | 8 | 23 | ||||||||||||||||||||||
| UIP | 1 | 1 | 64 | 55 | 53 | 0 | 63 | 0 |