Table 2. Patient history, CT patterns, distribution and extent of NSIP and UIP (one- and two-arm studies).
| NSIP | UIP | Wilcoxon test | |
|---|---|---|---|
| n observations, median (min; max) | n observations, median (min; max) | p-value | |
| Number of patients | 725 | 1593 | |
| Total number of studies (n) | n = 20 | n = 25 | |
| Age | n = 14, 54.6 (48.0; 59.2) | n = 19, 62.7 (53.1; 75.5) | <0.001 |
| Male (%) | n = 14, 34.7 (4.3; 64.0) | n = 18, 73.6 (50.8; 86.1) | <0.001 |
| Smoking (ever and past smokers) (%) | n = 9, 50.0 (8.2; 58.1) | n = 14, 73.2 (24.2; 91.7) | 0.001 |
| TOT disease extent (mean % of lung volume) | n = 9, 27.9 (0.4; 37.1) | n = 9, 32.0 (0.2; 44.0) | 0.566 |
| GGO (y/n) (%) | n = 8, 91.9 (44.3; 100.0) | n = 6, 31.0 (0.0; 100.0) | 0.065 |
| GGO extent (mean % of lung volume) | n = 12, 19.9 (5.6; 31.8) | n = 10, 14.7 (1.4; 23.4) | 0.086 |
| Honeycombing (y/n) (%) | n = 9, 8.5 (0.0; 32.0) | n = 10, 66.7 (15.9; 98.4) | 0.001 |
| Honeycombing extent (mean % of lung volume) | n = 10, 0.4 (0.0; 12.5) | n = 10, 5.6 (1.0; 30.3) | 0.006 |
| Consolidation y/n (%) | n = 8, 37.4 (4.0; 74.6) | n = 7, 2.9 (0.0; 58.8) | 0.049 |
| Consolidation extent (mean % of lung volume) | n = 11, 3.0 (0.0; 10.8) | n = 10, 1.1 (0.0; 6.0) | 0.09 |
| Reticulation (y/n) (%) | n = 7, 86.9 (10.0; 100.0) | n = 5, 100.0 (46.2; 100.0) | 0.449 |
| Reticulation extent (mean % of lung volume) | n = 7, 7.3 (3.3; 11.8) | n = 5, 10.8 (6.8; 30.1) | 0.123 |
| Predominant GGO: GGO>(R+H) (%) | n = 2, 21.7 (14.8; 28.6) | n = 3, 8.7 (4.8; 9.4) | 0.083 |
| Predominant reticulation: (R+H)>GGO (%) | n = 2, 37.4 (28.6; 46.3) | n = 2, 74.6 (56.3; 92.9) | 0.121 |
| H and/or R > G (%) | n = 2, 2.0 (0.0; 4.0) | n = 2, 27.6 (14.3; 40.9) | 0.121 |
| Subpleural sparing (y/n) (%) | n = 5, 30.8 (21.3; 64.0) | n = 3, 4.3 (0.0; 9.3) | 0.025 |
| Emphysema (y/n) (%) | n = 2, 11.7 (11.5; 11.9) | n = 4, 19.3 (0.0; 32.3) | 0.355 |
| Emphysema extent (mean % of lung volume) | n = 5, 1.8 (1.0; 3.2) | n = 5, 2.8 (1.6; 6.8) | 0.251 |
| Mosaic GGO (y/n) (%) | n = 1, 36.0 (36.0; 36.0) | n = 4, 16.4 (8.0; 43.5) | 0.48 |
| Peripheral predominance (outer 1/3) (%) | n = 8, 44.7 (33.3; 76.0) | n = 8, 82.5 (75.0; 95.5) | 0.001 |
| Central predominance/perbronchial (inner 2/3) (%) | n = 7, 37.0 (0.0; 61.1) | n = 7, 5.0 (4.1; 14.7) | 0.064 |
| Diffuse axial distribution both (%) | n = 7, 27.1 (5.6; 47.5) | n = 7, 6.7 (0.0; 21.7) | 0.035 |
| Upper lung predominant distribution (%) | n = 5, 0.0 (0.0; 2.8) | n = 5, 1.0 (0.0; 8.3) | 0.435 |
| Lower lung predominant (below carina) (%) | n = 5, 91.8 (80.0; 96.0) | n = 5, 84.0 (78.6; 100.0) | 0.917 |
| Diffuse distribution: both upper and lower lungs (%) | n = 5, 8.2 (6.3; 11.9) | n = 5, 16.2 (0.0; 20.4) | 0.6 |
GGO: ground-glass opacity, H: honeycombing; R: reticulation; y/n: yes/no