Table 3. Patient demographics, CT patterns, distribution and extent of NSIP and UIP.
| NSIP | UIP | Pooled OR | 95%-CI | p-value | I-squared (%) | |
|---|---|---|---|---|---|---|
| Binary data (y/n) | n observations, median (min; max) |
n observations, median (min; max) |
||||
| Male (%) | n = 6, 52.8 (24.0; 64.0) | n = 6, 73.6 (68.8; 85.9) | 0.32 | (0.17 to 0.60) | <0.001 | 48.78 |
| Smoking (ever and past smokers) (%) | n = 4, 55.1 (33.3; 58.1) | n = 4, 73.9 (61.3; 82.8) | 0.42 | (0.23 to 0.77) | 0.005 | 35.40 |
| GGO (y/n) (%) | n = 3, 83.9 (50.0; 100.0) | n = 3, 32.0 (0.0; 100.0) | *32.049 | (0.081 to 12655) | 0.256 | 92.44 |
| Honeycombing (y/n) (%) | n = 4, 28.9 (10.0; 32.0) | n = 4, 73.4 (56.0; 98.4) | 0.07 | (0.018 to 0.30) | <0.001 | 66.90 |
| Consolidation y/n (%) | n = 3, 40.0 (4.0; 74.2) | n = 3, 0.0 (0.0; 16.0) | 14.34 | (0.59 to 347) | 0.101 | 78.48 |
| Reticulation (y/n) (%) | n = 2, 55.0 (10.0; 100.0) | n = 2, 74.0 (48.0; 100.0) | *0.12 | (0.013 to 1.09) | 0.06 | 0.00 |
| Predominant GGO: GGO>(R+H) (%) | n = 2, 21.7 (14.8; 28.6) | n = 2, 7.1 (4.8; 9.4) | 3.68 | (1.22 to 11.09) | 0.021 | 0.00 |
| Predominant reticulation: (R+H)>GGO (%) | n = 2, 37.4 (28.6; 46.3) | n = 2, 74.6 (56.3; 92.9) | 0.15 | (0.032 to 0.67) | 0.014 | 67.28 |
| H and/or R > G (%) | n = 2, 2.0 (0.0; 4.0) | n = 2, 27.6 (14.3; 40.9) | 0.06 | (0.01 to 0.33) | 0.001 | 0.00 |
| Subpleural sparing (y/n) (%) | n = 3, 40.7 (30.8; 64.0) | n = 3, 4.3 (0.0; 9.3) | 16.33 | (2.28 to 117) | 0.005 | 67.36 |
| Peripheral predominance (outer 1/3) (%) | n = 6, 41.8 (33.3; 76.0) | n = 6, 83.3 (75.0; 95.5) | 0.21 | (0.11 to 0.38) | <0.001 | 16.22 |
| Central predominance/perbronchial (inner 2/3) (%) | n = 5, 41.0 (0.0; 61.1) | n = 5, 8.0 (4.5; 14.7) | 6.19 | (2.4 to 15.7) | <0.001 | 34.29 |
| Diffuse axial distribution both (%) | n = 5, 15.4 (5.6; 28.0) | n = 5, 4.5 (0.0; 21.7) | 2.34 | (1.07 to 5.11) | 0.033 | 0.00 |
| Upper lung predominant distribution (%) | n = 3, 0.0 (0.0; 2.8) | n = 3, 0.0 (0.0; 4.3) | 0.53 | (0.053 to 5.34) | 0.592 | 0.00 |
| Lower lung predominant (below carina) (%) | n = 4, 91.3 (80.0; 96.0) | n = 4, 92.0 (82.6; 100.0) | 0.96 | (0.27 to 3.36) | 0.955 | 6.13 |
| Diffuse distribution: both upper and lower lungs (%) | n = 3, 8.0 (6.3; 8.3) | n = 3, 0.0 (0.0; 17.4) | 0.91 | (0.23 to 3.63) | 0.892 | 0.00 |
| Continuous data | NSIP | UIP | Pooled MD | 95%-CI | p-value | I-squared (%) |
| Age | n = 6, 54.8 (50.0; 59.2) | n = 6, 59.7 (53.1; 62.9) | -4.37 | (-6.97 to -1.77) | 0.001 | 30.90 |
| TOT disease extent (% of lung volume) | n = 6, 27.9 (0.4; 37.1) | n = 6, 29.8 (0.2; 44.0) | -2.11 | (-4.59 to 0.37) | 0.095 | 0.00 |
| GGO extent (% of Lung volume) | n = 7, 19.8 (5.6; 31.3) | n = 7, 17.6 (1.4; 20.0) | 3.03 | (1.31 to 4.75) | 0.001 | 31.32 |
| Honeycombing extent (% of lung volume) | n = 6, 1.1 (0.2; 12.5) | n = 6, 5.8 (1.5; 30.3) | -3.86 | (-6.65 to -1.06) | 0.007 | 90.45 |
| Consolidation extent (% of lung volume) | n = 7, 3.0 (0.0; 10.8) | n = 7, 1.1 (0.0; 6.0) | 1.79 | (0.61 to 2.96) | 0.003 | 58.88 |
| Reticulation extent (% of lung volume) | n = 2, 8.2 (7.3; 9.0) | n = 2, 8.2 (6.8; 9.5) | -0.28 | (-2.12 to 1.56) | 0.763 | 0.00 |
GGO: ground-glass opacity, H: honeycombing; R: reticulation; y/n: yes/no; OR: odds ratio; CI: confidence interval; TOT: total; MD: mean difference
* One study was excluded because there were zero cells in both groups (all patients had the characteristic of interest)