Table 4. Random-effects meta-analysis according to DerSimonian and Laird and I^2.
| n studies | DerSimonian-Laird | 95%-CI | p-value | I-squared | 95%-CI | |
|---|---|---|---|---|---|---|
| Pooled OR | ||||||
| male | 6 | 0.32 | (0.17 to 0.60) | <0.001 | 48.8% | (0.0 to 79.7) |
| Smoking (ever and past-smokers) | 4 | 0.42 | (0.23 to 0.76) | 0.005 | 35.4% | (0.0 to 77.5) |
| GGO (y/n) | 3 § | 32.05 | (0.08 to 12654.94) | 0.256 | 92.4% | ** |
| Honeycombing (y/n) | 4 | 0.07 | (0.02 to 0.30) | <0.001 | 66.9% | (0.0 to 88.2) |
| Consolidation y/n | 3 | 14.34 | (0.59 to 346.96) | 0.101 | 78.5% | (16.5 to 92.4) |
| Reticulation (y/n) | 2 § | 0.12* | (0.01 to 1.10) | 0.060 | n.a. | ** |
| predominant GGO: GGO>(R+H) | 2 | 3.68 | (1.22 to 11.09) | 0.021 | 0.0% | ** |
| predominant reticulation: (R+H)>GGO | 2 | 0.15 | (0.03 to 0.68) | 0.014 | 67.3% | ** |
| H: H and/or R > G | 2 | 0.06 | (0.01 to 0.32) | 0.001 | 0.0% | ** |
| Relative subpleural spearing (y/n) | 3 | 16.33 | (2.29 to 116.56) | 0.005 | 67.4% | (0.0 to 89.3) |
| peripheral predominance (outer 1/3) | 6 | 0.21 | (0.11 to 0.39) | <0.001 | 16.2% | (0.0 to 78.7) |
| central predominance/perbronchial (inner 2/3) | 5 | 6.19 | (2.43 to 15.75) | <0.001 | 34.3% | (0.0 to 75.2) |
| both inner outer | 5 | 2.34 | (1.07 to 5.11) | 0.033 | 0.0% | (0.0 to 79.2) |
| upper predominant distribution | 3 § | 0.53 | (0.05 to 5.34) | 0.592 | 0.0% | ** |
| lower (below carina/) | 4 | 0.96 | (0.28 to 3.36) | 0.955 | 6.1% | (0.0 to 85.6) |
| both upper lower | 3 | 0.91 | (0.23 to 3.63) | 0.892 | 0.0% | (0.0 to 89.6) |
| Pooled WMD | ||||||
| Age mean estimation | 6 | -4.37 | (-6.98 to -1.77) | 0.001 | 30.9% | (0.0 to 73.5) |
| TOT disease extent (mean % of Lung volume) | 6 | -2.11 | (-4.59 to 0.37) | 0.095 | 0.0% | (0.0 to 84.7) |
| GGO extent (mean % of Lung volume) | 7 | 3.03 | (1.31 to 4.75) | 0.001 | 31.3% | (0.0 to 73.7) |
| Honeycombing extent (mean % of Lung volume) | 6 | -3.86 | (-6.65 to -1.06) | 0.007 | 90.4% | (78.6 to 95.7) |
| Consolidation extent (mean % of Lung volume) | 7 | 1.79 | (0.62 to 2.96) | 0.003 | 58.9% | (0.0 to 84.7) |
| Reticulation extent (mean % of Lung volume) | 2 | -0.28 | (-2.13 to 1.56) | 0.763 | 0.0% | ** |
| Emphysema extent (mean % of Lung volume) | 2 | -1.40 | (-4.97 to 2.16) | 0.440 | 71.5% | ** |
* Single-study effect because one of the two studies were was excluded.
**No estimation possible because of, not enough too few studies.