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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Pharm. 2019 May 30;16(7):3024–3039. doi: 10.1021/acs.molpharmaceut.9b00263

Figure 6.

Figure 6.

Rapa suppresses proteolytic CTSS activity in the LG but not in the tears. At the conclusion of the 2 week study, LG and tears were collected immediately after euthanasia for CTSS activity and gene expression analysis. (A) A significant decrease in CTSS activity was observed in the LG lysates after SC Rapa treatments (n = 9). (B) No statistical significance was observed for CTSS gene expression level in the LG over a 2 week period (n = 12). (C) No statistical significance was achieved for CTSS activity in tears over a 2 week period (n = 9). Two-way ANOVA was used to compare the effects of the drug and carrier (Mean ± SD).