Figure 7.

Histopathology of mouse organs reveals no systemic toxicity of FAF–Rapa at a therapeutic dose. At the conclusion of the study, organs and bloods from mice were sampled upon euthanasia. Organs were fixed, paraffin-embedded, sectioned, and stained with H&E. Kidney (n = 3), spleen (n = 3), lung (n = 3), and liver (n = 5) were analyzed by a blinded, trained pathologist. Images of organs from one representative mouse from each group were selected by a pathologist and shown. Black bar represents 100 μm.