Table 2.

Pharmacokinetic Parameters of IV- or SC-Delivered FAF–Rapa Analyzed Using Compartmental Analysis and Noncompartmental Analysis (Mean ± SD)

	route of administration
parameter (unit)	IV	SC	IV	SC
preferred model	one compartment	three compartments	noncompartment
AUC (μM·hr)	141 ± 16	92 ± 19	207 ± 33	109 ± 14
AUMC (μM·hr2)	-	-	2207 ± 344	2214 ± 328
F (%)	100	65.5 ± 13.2	100	52.7 ± 6.7
CL (mL/h)	0.15 ± 0.01	0.15a	0.10 ± 0.01	0.09 ± 0.01
CL/F (mL/h)	0.15 ± 0.01	0.23 ± 0.04	0.10 ± 0.01	0.18 ± 0.03
Vd (mL)	1.46 ± 0.2	1.46a	0.88 ± 0.1	0.85 ± 0.1
Cmax (μM)	13.4 ± 2.4	3.3 ± 0.1	11.7 ± 2.9	4.4 ± 0.7
Tmax (hr)	0.0	12.4 ± 0.7	0.0	12.0
MRT (hr)	-	-	10.7 ± 0.3	20.3 ± 1.1
MAT (hr)	-	-	-	9.6 ± 1.1
Tl/2,absorption (hr)	-	4.2 ± 0.4	-	-
Tl/2,elimination (hr)	6.9 ± 0.5	6.9a	6.2 ± 0.4	6.4 ± 0.7
kabsorption (hr−1)	-	0.16b	-	-
kelimination (hr−1)	0.10 ± 0.01	0.10a	0.11 ± 0.01	0.11 ± 0.01
kdegradation (hr−1)	-	0.09 ± 0.05	-	-

^aCompartmental values from IV analysis were adopted to estimate other SC parameters.

^bTo fit the observed time to peak concentration, the assumption was required that k_absorption = k_{injection site→interstitial} = k_{interstitial fluid→systemic circulation}.