Table 1.
Study participant clinical and demographic characteristics
| Total Cohort | Rs6795970 Homozygote | Heterozygote and Wild Type | P Value | |
|---|---|---|---|---|
| n | 166 | 27 | 139 | |
| Age, yr | 61.5 ± 1.0 | 61 ± 2.6 | 61.6 ± 1.1 | 0.89 |
| Sex, female/male | 104/62 | 17/10 | 87/52 | 0.99 |
| Body weight, kg | 83 ± 1.7 | 88 ± 4.2 | 83 ± 1.9 | 0.25 |
| Body mass index, kg/m2 | 29.4 ± 0.5 | 29.4 ± 1.3 | 29.5 ± 0.6 | 0.81 |
| Race/Ethnicity | 164 White, 2 Hispanic |
27 White | 137 White, 2 Hispanic |
0.99 |
| Active tobacco use, yes/no | 32/134 | 4/23 | 28/111 | 0.61 |
| Active alcohol use, yes/no | 92/74 | 17/10 | 75/64 | 0.41 |
| Opiate before surgery, yes/no | 10/156 | 2/25 | 8/131 | 0.67 |
| NSAID before surgery, yes/no | 60/106 | 12/15 | 48/91 | 0.38 |
| Other pain medication use before surgery, yes/no | 63/103 | 10/17 | 53/86 | 0.99 |
| Surgery type, laparoscopic/open | 116/50 | 19/8 | 97/42 | 0.99 |
| Intraoperative opiate use (morphine equivalent), mg | 26.8 ± 0.9 | 28.1 ± 2.5 | 26.6 ± 1.0 | 0.48 |
| Intraoperative opiate use normalized to body weight, mg/kg | 0.34 ± 0.01 | 0.33 ± 0.03 | 0.34 ± 0.01 | 0.85 |
| Postoperative (24 h) opiate use normalized to body weight, mg/kg | 0.83 ± 0.05 | 0.65 ± 0.09 | 0.86 ± 0.06 | 0.12 |
Values are means ± SE or number of patients with the indicated characteristic.