Table 1.

Effect of pyridoxine-related and unrelated compounds on uptake of [³H]pyridoxine by PAC 266-6

Compound	Pyridoxine Uptake, pmol·mg protein−1·30 min−1	P Value
Control	94.70 ± 2.2
Pyridoxine	38.10 ± 3.9	<0.01
Pyridoxal	31.98 ± 0.8	<0.01
P-5-P	34.96 ± 1.1	<0.01
Pyridoxamine	35.49 ± 0.5	<0.01
4-Pyridoxic acid	91.31 ± 1.5	NS
Penicillamine	87.17 ± 0.25	NS
Biotin	93.15 ± 4.1	NS

Data are means ± SE of 6–8 separate uptake determinations. Cells were incubated in Krebs-Ringer buffer (pH 7.4, 30 min, 37°C) in the presence of [³H]pyridoxine (7.5 nM) and 1 mM of the compound under investigation. PAC, pancreatic acinar cells; P-5-P, pyridoxal 5-phosphate; NS, not significant.