Table 1.
Clinical characteristics at inclusion (previously published [15])
| Characteristics | Intervention | Control |
|---|---|---|
| (n = 57) | (n = 60) | |
| Age yr—median (range) | 45 (19−65) | 41 (18−62) |
| Female | 20 (35) | 25 (42) |
| AML | 36 (63) | 31 (51) |
| High risk first remission | 23 | 22 |
| After relapse, beginning of first relapse and in second remission | 10 | 9 |
| First remission standard risk | 3 | — |
| ALL | 6 (10) | 10 (17) |
| First remission high risk | 3 | 7 |
| Early first relapse, second remission | 3 | 3 |
| CML | 2 (4) | 7 (12) |
| Chronic phase | — | 1 |
| Accelerated phase | 2 | 6 |
| CMML | 3 (5) | 3 (5) |
| MDS | 6 (11) | 5 (8) |
| Othera | 4 (7) | 4 (7) |
| Donor | ||
| HLA-identical sibling | 17 (30) | 13 (22) |
| HLA-identical unrelated | 40 (70) | 47 (78) |
| Stem-cell source | ||
| Bone marrow | 25 (44) | 27 (45) |
| Peripheral-blood hematopoietic cells | 32 (56) | 33 (55) |
| Sex mismatchb | 17 (30) | 10 (17) |
| Positive CMV serology | ||
| Donor | 27 (47) | 24 (40) |
| Recipients | 45 (79) | 43 (72) |
| Conditioning | ||
| Busulphan + Cyclophosphamide | 56 (98) | 56 (93) |
| TBI + Cyclophosphamide | 1 (2) | 4 (7) |
| HCTI—CI risk groupsa | ||
| Low risk | 42 (74) | 45 (75) |
| Intermediate risk | 8 (14) | 10 (17) |
| High risk | 7 (12) | 5 (8) |
| EBMT scorea | ||
| 0−3 | 33 (58) | 36 (60) |
| 4 | 14 (24) | 14 (23) |
| 5−7 | 10 (18) | 10 (17) |
| Performance status ECOG | ||
| 0 | 55 (96) | 54 (90) |
| 1 | 2 (4) | 6 (10) |
| BMI | ||
| Underweight | 2 (4) | 4 (7) |
| Normal weight | 31 (54) | 27 (45) |
| Overweight | 17 (30) | 26 (43) |
| Moderately obese | 4 (7) | 3 (5) |
| Severely obese | 3 (5) | 0 (0) |
Values are numbers (%) unless otherwise stated
AML acute myeloid leukemia, ALL acute lymphocytic leukemia, CML chronic myeloid leukemia, CMML chronic myelomonocytic leukemia, MDS myelodysplastic syndrome, CMV cytomegalovirus, TBI total body irradiation, HCTI-CI hematopoietic cell transplantation-specific comorbidity index, EBMT score European Group for Blood and Marrow Transplantation score, ECOG Eastern Cooperative Oncology Group
aAn expanded list of baseline values for other diagnosis, EBMT score and HCTI-CI score is provided in Supplementary Table S1
bSex mismatch was defined as female donor to male recipients