Table 1.

Patients population

	Year of last transplant				Total		p value
	1980–2001		2002–2015
	N	%	N	%	N	%
	42997	37.55	71494	62.45	114491	100.00
Sex
Male	24656	57.34	40038	56.00	64694	56.51	<0.0001
Female	18341	42.66	31456	44.00	49797	43.49
Age at last HSCT (years)
Median	33.1		41.0		37.4		<0.0001
Range	0.2–77.9		0.0–83.8		0.0–83.8
Mean (SD)	32.24 (15.04)		38.95 (18.14)		36.43 (17.35)
N obs	42972		71465		114437
Underlying disease
AML	20132	46.82	45386	63.48	65518	57.23	<0.0001
ALL	9431	21.93	19652	27.49	29083	25.40
CML	13434	31.24	6456	9.03	19890	17.37
Stage at last transplant
early	27495	63.95	43946	61.47	71441	62.40	<0.0001
late	15502	36.05	27548	38.53	43050	37.60
Type of HSCT
Allogeneic	31128	72.40	64661	90.44	95789	83.67	<0.0001
Autologous	11869	27.60	6833	9.56	18702	16.33
Stem cell source
BM	30218	70.28	15466	21.63	45684	39.90	<0.0001
PB	12442	28.94	53829	75.29	66271	57.88
CB	337	0.78	2199	3.08	2536	2.22
T-cell depletion
no	14097	62.24	30792	50.67	44889	53.81	<0.0001
yes in vivo, no ex vivo	2881	12.72	26488	43.59	29369	35.21
yes ex vivo, no in vivo	3201	14.13	1357	2.23	4558	5.46
yes in vivo + ex vivo	2472	10.91	2129	3.50	4601	5.52
Conditioning regimen
standard	32708	96.38	45487	70.77	78195	79.62	<0.0001
reduced	1230	3.62	18788	29.23	20018	20.38
First HSCT
No	2906	6.76	6342	8.87	9248	8.08	<0.0001
Yes	40091	93.24	65152	91.13	105243	91.92
Geographic regions
north-west	26319	61.21	38629	54.03	64948	56.73	<0.0001
south	14470	33.65	25987	36.35	40457	35.34
east	2208	5.14	6878	9.62	9086	7.94
GNI per capita 2015a
High income	41424	96.34	63712	89.12	105136	91.83	<0.0001
Upper middle income	1565	3.64	7671	10.73	9236	8.07
Lower middle income	8	0.02	111	0.16	119	0.10
JACIE accreditation 2016
accredited	22935	53.34	36420	50.94	59355	51.84	<0.0001
expired	7827	18.20	8439	11.80	16266	14.21
withdrawn	279	0.65	369	0.52	648	0.57
not accredited	11956	27.81	26266	36.74	38222	33.38
Centre experienceb
0–4	6295	14.64	2236	3.13	8531	7.45	<0.0001
5–19	31026	72.16	29652	41.47	60678	53.00
20+	5676	13.20	39606	55.40	45282	39.55
Centre sizec
0–4	14940	34.75	14965	20.93	29905	26.12	<0.0001
5–19	24345	56.62	37794	52.86	62139	54.27
20+	3712	8.63	18735	26.20	22447	19.61

^aAtlas methodology

^bcalculated from ProMISE: number of years performing transplants until the year of transplant of the patient

^ccalculated from ProMISE: number of transplants with the same disease and same year of transplant as the patient

All the differences resulted statistically significant (p < 0.0001)