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. 2020 Jan 13;10:183. doi: 10.1038/s41598-019-57067-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The complexity of oxygen saturation signals. The left column is the curve of MSE/MFE. The middle column is the CAI. The right column is the multiple comparisons. (a) MSE before stimulation. (b)MSE CAI before stimulation. (c) Comparison of MSE CAI before stimulation, F_(4,141) = 0.5776, P = 0.6794. (d) MFE before stimulation. (e) MFE CAI before stimulation. (f) Comparison of MFE CAI before stimulation, F_(4,141) = 0.5756, P = 0.6808. (g) MSE after stimulation. (h) MSE CAI after stimulation. (i) Comparison of MSE CAI after stimulation, F_(4,141) = 32.38, P < 0.01. (j) MFE after stimulation. (k) MFE CAI after stimulation. (m) Comparison of MFE CAI after stimulation, F_(4,141) = 39.64, P < 0.01. Yellow indicates P < 0.05, and blue indicates P > 0.05. MSE, multiscale entropy; CAI, complexity area index; MFE, multiscale fuzzy entropy. BC, blank control. Data are presented as the mean ± SE.