Table 1.
Summary of pathologic and cytogenetic features of cases with MYC amplification.
| Final Classification n = 42a | WHO DHL (n = 12) | DLBCL (n = 22) | HGBCL, NOS (n = 3) | Plasmablastic (n = 2) | Unknown Cytologyb (n = 3) |
|---|---|---|---|---|---|
| High-grade morphology | 1/11 (9%) | 0/22 (0%) | 3/3 (100%) | NA | Unknown |
| GCB by Hans | 8/9 (89%) | 15/18 (83%) | 2/2 (100%) | NA | Unknown |
| Double expresser | 5/7 (71%) | 6/16 (38%) | 2/2 (100%) | 1/1 (100%) | 1/1 (100%) |
| MYC-non-IGH | 10/12 (83%) | 7/22 (32%) | 1/3 (33%) | 2/2 (100%) | 1/3 (33%) |
| MYC-IGH | 2/12 (17%) | 2/22 (9%) | 0/3 (0%) | 0/2 (0%) | 0/3 (0%) |
| MYC-any R; NO BCL2 or BCL6-R | NA | 9/22 (41%) | 1/3 (33%) | 2/2 (2%) | 1/3 (33%) |
| MYC-any R; BCL2-R or BCL6-R present | 12/12 (100%) | NA | NA | 0/2 (0%) | NA |
| NO MYC-R; BCL2-R and/or BCL6-R present | NA | 5/21 (24%) | 0/3 (0%) | NA | 2/2 (100%) |
Cases are classified by final WHO pathologic classification based on morphologic, immunohistochemical, and cytogenetic features
NA Not applicable
GCB Germinal center B cell
BCL2-R: BCL2 rearranged
MYC-any R = MYC sep = MYC any rearrangement
aTwo cases are not included in the table as complete BCL2 or BCL6 FISH was not available for review precluding final classification as either DLBCL or HGBL NOS
bUnknown Cytology: cases in which H&E was not available for morphologic review, thus cannot be classified as either DLBCL or HGBL NOS