Fig. 2. Treatment with anti-thyroid drug protected photoreceptors from cell loss/degeneration induced by NaIO₃.

Retinal morphology, photoreceptor layer integrity, and loss of photoreceptors were evaluated by light microscope and morphometric analysis at 3 days post-NaIO₃ injection, and cone density was evaluated by PNA labeling on retinal whole mounts. a Shown are representative light microscopic images of H&E stained retinal sections, and corresponding quantitative analysis of ONL thickness in the dorsal and ventral regions. Data represented the mean ± SEM for 3–5 mice each group. b Shown are representative confocal images of PNA labeling on retinal whole mounts, and corresponding quantitative analysis. RPE, retinal pigment epithelial; OS, outer segment; IS, inner segment; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; RGC, retinal ganglion cell. Data represented the mean ± SEM for 7–12 mice per group (*p < 0.05; **p < 0.01; ***p < 0.001).