Table 4.
Results from the analysis of correcting the observed associations for the additional covariates of obesity and diabetes status of the participants.
| SNP: Effect Allele: Trait | Gene | Phase | Effect SizeBMI | P-valueBMI | Effect SizeLM | P-valueLM | Effect SizeDS | P-valueDS | Effect Size DS+BMI+DM+LM | P-valueDS+BMI+DM+LM |
|---|---|---|---|---|---|---|---|---|---|---|
| rs1002487: C#, FPG | RPS6KA1: intronic | Discovery | 8.416 | 1.02E-08 | 8.379 | 1.23E-08 | 6.388 | 1.53E-07 | 6.482 | 1.01E-07 |
| Replication | 3.355 | 2.62E-03 | 3.442 | 3.73E-04 | 3.492 | 2.16E-04 | 3.46 | 2.10E-04 | ||
| Meta | 6.233 | 4.58E-10 | 6.233 | 4.56E-10 | 6.357 | 2.05E-10 | 6.418 | 1.38E-10 | ||
| rs487321: A#, FPG | CADPS: intronic | Discovery | 6.145 | 1.35E-07 | 6.177 | 1.22E-07 | 4.468 | 3.83E-06 | 4.48 | 3.61E-06 |
| Replication | 3.904 | 2.59E-06 | 3.979 | 2.06E-06 | 3.994 | 1.28E-08 | 4.00 | 8.97E-09 | ||
| Meta | 7.042 | 1.90E-12 | 7.089 | 1.35E-12 | 7.303 | 2.81E-13 | 7.356 | 1.88E-13 | ||
| rs707927: G@,$, FPG | VARS, VWA7: intron in VARS, 2 Kb upstream of VWA7 | Discovery | 0.9289 | 1.14E-05 | 0.931 | 1.12E-05 | 0.658 | 1.73E-04 | 0.6523 | 2.01E-04 |
| Replication | 0.6446 | 6.29E-05 | 0.683 | 2.64E-05 | 0.614 | 6.59E-06 | 0.584 | 1.51E-05 | ||
| Meta | 5.926 | 3.11E-09 | 6.073 | 1.25E-09 | 5.851 | 4.87E-09 | 5.696 | 1.23E-08 | ||
| rs12600570: T@, FPG | DHX58: intronic | Discovery | 0.7914 | 1.42E-05 | 0.831 | 5.19E-06 | 0.530 | 4.44E-04 | 0.5092 | 7.83E-04 |
| Replication | 0.3757 | 5.20E-03 | 0.391 | 3.88E-03 | 0.309 | 6.59E-03 | 0.291 | 9.74E-03 | ||
| Meta | 5.025 | 5.05E-07 | 5.238 | 1.62E-07 | 4.392 | 1.12E-05 | 4.191 | 2.78E-05 |
#Association with the trait was observed under the genetic model based on recessive mode of inheritance; @association with the trait was observed under the genetic model based on additive mode of inheritance.
EffectSizeEffect size represents beta value for discovery and replication phases, and Z-score for meta-analysis. RRegular correction - Corrected for age, sex and the top 10 principal components that resulted from the Principal Components Analysis of the genotype data; BMI,Corrected for BMI in addition to the regular correction; LMCorrected for lipid medication in addition to the regular correction; DSCorrected for diabetes status in addition to the regular correction; BMI+LM+DMCorrected for BMI and lipid & diabetes medications in addition to the regular correction.