Table 6.
Results from the analysis of examining the identified associations in sub-cohorts of entirely diabetic patients or of entirely healthy participants.
| SNP: Effect Allele: Trait | Gene: functional consequences | Phase | Effect SizeR | P-valueR | Effect SizeBMI+LM | P-valueBMI+LM | Effect SizeBMI+LM+DM | P-valueBMI+LM+DM |
|---|---|---|---|---|---|---|---|---|
| rs1002487: C#, FPG | RPS6KA1: intronic | Discovery_diabetic | 6.396 | 2.48E-04 | 6.487 | 2.11E-04 | 6.488 | 2.12E-04 |
| Discovery_non- diabetic& | NA | NA | NA | NA | ||||
| Replication_diabetic | 17.83 | 4.74E-07 | 17.72 | 6.07E-07 | 17.7 | 6.50E-07 | ||
| Replication_non- diabetic | 0.0086 | 0.9886 | −0.08115 | 0.8861 | ||||
| Meta_diabetic | 6.011 | 1.84E-09 | 6.014 | 1.81E-09 | 6.004 | 1.93E-09 | ||
| Meta_non-diabetic | 0.014 | 0.9886 | 0.143 | 0.8861 | ||||
| Meta_all | 4.173 | 3.0E-05 | 4.062 | 4.86E-05 | ||||
| rs487321: A#, FPG | CADPS: intronic | Discovery_diabetic | 5.781 | 3.1E-04 | 5.799 | 3.1E-04 | 5.797 | 3.1E-04 |
| Discovery_non- diabetic | −0.117 | 0.9872 | 0.1009 | 0.8885 | ||||
| Replication_diabetic | 9.392 | 2.1E-04 | 9.346 | 2.36E-04 | 9.594 | 1.84E-04 | ||
| Replication_non- diabetic | 2.479 | 4.64E-08 | 2.429 | 1.07E-08 | ||||
| Meta_diabetic | 5.132 | 2.86E-07 | 5.116 | 3.12E-07 | 5.154 | 2.55E-07 | ||
| Meta_non-diabetic | 4.190 | 2.78E-05 | 4.486 | 7.27E-06 | ||||
| Meta_all | 6.420 | 1.36E-10 | 6.648 | 2.97E-11 | ||||
| rs707927: G@, FPG | VARS, VWA7: intron in VARS, 2 Kb upstream of VWA7 | Discovery_diabetic | 1.153 | 1.50E-03 | 1.157 | 1.51E-03 | 1.155 | 1.54E-03 |
| Discovery_non- diabetic | 0.1979 | 3.3E-02 | 0.1858 | 4.18E-02 | ||||
| Replication_diabetic | 1.516 | 4.23E-04 | 1.518 | 4.35E-04 | 1.517 | 4.47E-04 | ||
| Replication_non- diabetic | 0.2364 | 1.1E-02 | 0.2011 | 2.04E-02 | ||||
| Meta_diabetic | 4.683 | 2.83E-06 | 4.677 | 2.91E-06 | 4.668 | 3.05E-06 | ||
| Meta_non-diabetic | 3.327 | 8.78E-04 | 3.083 | 2.05E-03 | ||||
| Meta_all | 5.458 | 4.82E-08 | 5.259 | 1.45E-07 | ||||
| rs12600570: T@, FPG | DHX58: intronic | Discovery_diabetic | 0.8421 | 8.46E-03 | 0.8328 | 9.55E-03 | 0.8303 | 9.85E-03 |
| Discovery_non- diabetic | 0.2308 | 3.35E-03 | 0.217 | 5.21E-03 | ||||
| Replication_diabetic | 0.5816 | 0.101 | 0.5767 | 0.1052 | 0.5874 | 0.1002 | ||
| Replication_non- diabetic | 0.1955 | 1.2E-02 | 0.1955 | 1.17E-02 | ||||
| Meta_diabetic | 3.080 | 2.07E-03 | 3.035 | 2.4E-03 | 3.042 | 2.35E-03 | ||
| Meta_non-diabetic | 3.814 | 1.30E-04 | 3.724 | 1.96E-04 | ||||
| Meta_all | 4.898 | 9.71E-07 | 4.799 | 1.59E-06 |
&In the case of the RPS6KA1 marker, all the individuals with genotype homozygous for risk allele were seen with the sub-cohort of Discovery_diabetic) and hence results for Discovery_ non-diabetic sub-cohort were unavailable.
#Association with the trait was observed under the genetic model based on recessive mode of inheritance; @association with the trait was observed under the genetic model based on additive mode of inheritance.
EffectSizeEffect size represents beta value for discovery and replication phases, and Z-score for meta-analysis. RRegular correction - Corrected for age, sex and the top 10 principal components that resulted from the Principal Components Analysis of the genotype data; BMI+LMCorrected for BMI and lipid medication in addition to the regular correction; BMI+LM+DMCorrected for BMI and lipid & diabetes medications in addition to the regular correction.