Table 8.
Interactions between (TG, FPG, HbA1c) and Insulin Resistance traits (HOMA-IR, HOMA-β, C-peptide, HOMA-S) with respect to genotypes at the risk variants.
| Interaction | Effect Size | Std. Error | P-value@ |
|---|---|---|---|
| Recessive Marker rs1002487-C/RPS6KA1 | |||
| Model: TG~rs1002487* insulin resistance traits | |||
| CC: HOMA-IR | 11.78 | 4.12 | 0.0047 |
| TC: HOMA-IR | 12.95 | 7.17 | 0.072 |
| CC: HOMA-β | −4.31 | 0.69 | 1.5E-09 |
| TC: HOMA-β | 0.078 | 0.17 | 0.655 |
| CC: C-peptide | 1959.1 | 292.95 | 1.25E-10 |
| TC: C-peptide | 26.11 | 18.32 | 0.152 |
| CC: HOMA-S | −2.633 | 0.418 | 1.16E-09 |
| TC: HOMA-S | −0.299 | 0.145 | 0.0397 |
| Model: FPG~rs1002487* insulin resistance traits | |||
| CC: HOMA-IR | 0.209 | 0.308 | 0.497 |
| TC: HOMA-IR | −0.394 | 0.537 | 0.463 |
| CC: HOMA-β | −0.247 | 0.043 | 3.62E-08 |
| TC: HOMA-β | 0.0013 | 0.011 | 0.900 |
| CC: C-peptide | 122.2 | 5.046 | 8.19E-07 |
| TC: C-peptide | 0.682 | 1.515 | 0.653 |
| CC: HOMA-S | −0.162 | 0.032 | 1.25E-06 |
| TC: HOMA-S | −0.0005 | 0.011 | 0.995 |
| Model: HbA1C~rs1002487* insulin resistance traits | |||
| CC: HOMA-IR | 0.341 | 0.201 | 0.090 |
| CT: HOMA-IR | −0.624 | 0.349 | 0.075 |
| CC: HOMA-β | −0.138 | 0.029 | 3.04E-06 |
| CT: HOMA-β | −0.0008 | 0.007 | 0.257 |
| CC: C-peptide | 66.96 | 14.77 | 8.73E-06 |
| CT: C-peptide | −0.886 | 0.924 | 0.338 |
| CC: HOMA-S | −0.092 | 0.02 | 1.35E-05 |
| CT: HOMA-S | 0.0037 | 0.007 | 0.606 |
| Additive Marker rs707927-G/[VARS, VWA7] | |||
| Model: TG~rs707927* insulin resistance trait | |||
| AG: HOMA-IR | 9.845 | 3.351 | 0.0035 |
| GG: HOMA-IR | 17.318 | 78.544 | 0.825 |
| AG: HOMA-β | −0.307 | 0.165 | 0.064 |
| GG: HOMA-β | −0.435 | 0.817 | 0.595 |
| AG: C-peptide | 8.396 | 17.182 | 0.625 |
| GG: C-peptide | −139.584 | 258.03 | 0.588 |
| AG: HOMA-S | −0.313 | 0.116 | 0.007 |
| GG: HOMA-S | 0.009 | 0.521 | 0.986 |
| Model: FPG~rs707927* insulin resistance trait | |||
| AG: HOMA-IR | 0.239 | 0.233 | 0.306 |
| GG: HOMA-IR | 24.48 | 5.470 | 1.11E-05 |
| AG: HOMA-β | −0.034 | 0.009 | 0.00032 |
| GG: HOMA-β | −0.194 | 0.047 | 5.17E-05 |
| AG: C-peptide | 0.100 | 1.272 | 0.937 |
| GG: C-peptide | −77.43 | 19.10 | 6.59E-05 |
| AG: HOMA-S | −0.020 | 0.008 | 0.012 |
| GG: HOMA-S | −0.140 | 0.037 | 0.00019 |
| Model: HbA1C~rs707927* insulin resistance trait | |||
| AG: HOMA-IR | 0.482 | 0.159 | 0.0024 |
| GG: HOMA-IR | 7.012 | 3.736 | 0.0615 |
| AG: HOMA-β | −0.021 | 0.006 | 0.0013 |
| GG: HOMA-β | −0.048 | 0.032 | 0.127 |
| AG: C-peptide | 0.827 | 0.788 | 0.295 |
| GG: C-peptide | −22.07 | 11.84 | 0.063 |
| AG: HOMA-S | −0.018 | 0.005 | 0.0005 |
| GG: HOMA-S | −0.043 | 0.023 | 0.0686 |
| Recessive Marker rs487321-A/CADPS | |||
| Model: TG~rs487321* insulin resistance trait | |||
| GA: HOMA-IR | −17.71 | 6.001 | 0.003 |
| AA: HOMA-IR | NA | NA | NA |
| GA: HOMA-β | 0.091 | 0.186 | 0.623 |
| AA: HOMA-β | NA | NA | NA |
| GA: C-peptide | −0.661 | 18.710 | 0.972 |
| AA: C-peptide | NA | NA | NA |
| GA: HOMA-S | 0.109 | 0.150 | 0.468 |
| AA: HOMA-S | NA | NA | NA |
| Model: FPG~rs487321* insulin resistance trait | |||
| GA: HOMA-IR | −0.316 | 0.446 | 0.476 |
| AA: HOMA-IR | NA | NA | NA |
| GA: HOMA-β | −0.024 | 0.011 | 0.032 |
| AA: HOMA-β | NA | NA | NA |
| GA: C-peptide | −1.55 | 1.464 | 0.288 |
| AA: C-peptide | NA | NA | NA |
| GA: HOMA-S | 0.0006 | 0.011 | 0.952 |
| AA: HOMA-S | NA | NA | NA |
| Model: HbA1C~rs487321* insulin resistance trait | |||
| GA: HOMA-IR | 0.038 | 0.294 | 0.896 |
| AA: HOMA-IR | NA | NA | NA |
| GA: HOMA-β | −0.007 | 0.007 | 0.330 |
| AA: HOMA-β | NA | NA | NA |
| GA: C-peptide | 0.088 | 0.881 | 0.920 |
| AA: C-peptide | NA | NA | NA |
| GA: HOMA-S | −0.0041 | 0.007 | 0.5610 |
| AA: HOMA-S | NA | NA | NA |
| Additive Marker rs12600570-T/DHX58 | |||
| Model: TG~rs12600570* insulin resistance trait | |||
| CT: HOMA-IR | −7.86 | 5.063 | 0.122 |
| TT: HOMA-IR | 59.60 | 17.11 | 0.00057 |
| CT: HOMA-β | 0.116 | 0.128 | 0.3654 |
| TT: HOMA-β | 0.667 | 0.490 | 0.1742 |
| CT: C-peptide | 3.11 | 17.42 | 0.858 |
| TT: C-peptide | 178.71 | 44.06 | 6.50E-05 |
| CT: HOMA-S | 0.155 | 0.093 | 0.095 |
| TT: HOMA-S | −0.971 | 0.393 | 0.014 |
| Model: FPG~rs12600570* insulin resistance trait | |||
| CT: HOMA-IR | 1.005 | 0.375 | 0.0078 |
| TT: HOMA-IR | 2.797 | 1.268 | 0.0282 |
| CT: HOMA-β | −0.018 | 0.0076 | 0.0158 |
| TT: HOMA-β | −0.135 | 0.0291 | 5.09E-06 |
| CT: C-peptide | −0.781 | 1.391 | 0.574 |
| TT: C-peptide | −10.22 | 3.517 | 0.0039 |
| CT: HOMA-S | −0.004 | 0.007 | -0.660 |
| TT: HOMA-S | −0.081 | 0.029 | -2.712 |
| Model: HbA1C~rs12600570* insulin resistance trait | |||
| CT: HOMA-IR | 0.213 | 0.254 | 0.402 |
| TT: HOMA-IR | 0.153 | 0.859 | 0.858 |
| CT: HOMA-β | 0.002 | 0.0052 | 0.601 |
| TT: HOMA-β | −0.012 | 0.0196 | 0.531 |
| CT: C-peptide | −0.363 | 0.848 | 0.668 |
| TT: C-peptide | −1.861 | 2.144 | 0.386 |
| CT: HOMA-S | 0.0015 | 0.004 | 0.720 |
| TT: HOMA-S | −0.0176 | 0.0188 | 0.350 |
@Multiple testing significance threshold for p-value is 0.003.
All the interaction models were corrected for age and gender.