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. 2020 Jan 13;11(1):25. doi: 10.1038/s41419-019-2221-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Western blot analysis for total Akt and phosphorylated Akt (Ser473) in A2780 and SKOV3 cells with treatment as indicated. b Western blot analysis for expression of p-Akt (Ser473), SREBP1c, SREBP2, FASN and HMGCR in SKOV3 cells treated with an Akt inhibitor LY294002 (LY294002, 5 μM PI3K/Akt signaling inhibitor for 12 h). c–f Cellular content of free fatty acid (c), triglyceride (d), phospholipids (e) and cholesterol (f) were detected in SKOV3 treated with Akt inhibitor LY294002. g The content of neutral lipids were detected by BODIPY 493/503 dye and counterstained with DAPI in SKOV3 cells treated with Akt inhibitor LY294002. Scale bars, 50μm. Average numbers of LDs per cell (upper panel), percentage of cellular area occupied by LDs (lower panel). Data are shown as mean ± S.E.M from three independent experiments. *p < 0.05; **p < 0.01.