Table 3.

Reproducibility of automated methods on 10 subjects per dataset. From left to right, the table lists median [1st and 3rd quartiles] for volumes; mean ± std for volumes; p values for the pairwise comparison of volumes from first and second time processed full images; ICC (absolute agreement (lower-upper band of 95% CI)) between volumes from full and FFR-processed images; and Dice’s similarity index between segmentation from first and second time processed full images

N = 10		Volume		p value	ICC	SI
AD NBV (L)	First	1.34 [1.29; 1.38]	1.32 ± 0.10
	Second	1.34 [1.30; 1.40]	1.34 ± 0.07	0.30	0.988 (0.973–0.992)
AD BV (L)	First	1.09 [1.00; 1.13]	1.06 ± 0.13
	Second	1.08 [1.30; 1.40]	1.07 ± 0.14	0.35	0.998 (0.992–1.000)
MS LV (mL)	First	3.00 [1.64; 8.08]	6.39 ± 6.87
	Second	3.82 [2.11; 8.35]	6.68 ± 6.74	0.16	0.996 (0.971–0.999)	0.95 [0.84–0.98]
GB GBV (mL)	First	39.89 [25.11; 85.92]	68.50 ± 69.66
	Second	40.65 [25.28; 86.61]	69.38 ± 70.16	0.06	0.998 (0.998–1.000)	0.94 [0.89–0.96]

ICC, intra-class correlation coefficient; N = amount of subjects; std, standard deviation; AD, Alzheimer’s disease; MS, multiple sclerosis; SI, Dice’s similarity index; FN, false negative; FP, false positive