Fig. 3.

drNPC transplantation promotes functional recovery. a Mice were tested for functional performance on the foot fault test at 3 days prior to stroke and 3, 8, 18, and 32 days post-stroke, and sacrificed 32 days post-stroke, when tissue analysis was performed. b–d All stroke-injured mice have significant functional deficits by 3 days following stroke. b drNPC transplants promote functional recovery back to uninjured control levels by 32 days post-stroke, whereas vehicle-only injections did not. c The transplant vehicle had no impact on functional recovery, as only those mice that received drNPCs recovered to naïve levels and those that received vehicle injections did not, irrespective of transplant vehicle (HAMC or aCSF). d Mice that received drNPCs had significantly better performance on the foot fault test than those that received vehicle-only injections at 32 days post-stroke. Data is presented as mean ± SEM; * = b significantly different from naïve d significant difference between groups; c a (aCSF alone), b (HAMC alone), c (drNPCs + aCSF), d (drNPCs + HAMC) = significantly different from naïve; n.s. = not significant, b) p < 0.0001, c) p < 0.003, and d) p < 0.05