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. 2020 Jan 13;10(1):6. doi: 10.1038/s41408-019-0272-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The DEMs miR-155, miR-4524a, and miR-744 might disrupt CDK1/2 regulated G2 checkpoint by modulating the expression of CDC25A and WEE1. The let-7c and miR-155 may also act through PLK1 at the G2 checkpoint whereas miR-423 could abrogate expression of MCM2 at the S checkpoint. The let-7e, miR-30a, miR-423, miR-155, miR-744, and miR-486 are known to regulate TP53, MYC, and ATM and hence may modulate G1 phase of the cell cycle.