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. Author manuscript; available in PMC: 2021 Feb 5.
Published in final edited form as: Biochem Biophys Res Commun. 2019 Nov 21;522(2):415–421. doi: 10.1016/j.bbrc.2019.11.110

Fig. 4. Effects of genetic inhibition of CHMP5 and CHMP6 on ferroptosis in vivo.

Fig. 4.

(A) Athymic nude mice were injected subcutaneously with the indicated PANC1 or HepG2 cells for 7 days and then treated with RSL3 (30 mg/kg; i.p., once every other day) at day 7 for 2 weeks. Tumor volumes were calculated weekly (n = 5 mice/group, *P < 0.05). (B-C) In parallel, MDA levels (B) in isolated tumors or serum HMGB1 at day 14 after treatment were assayed (n = 3 mice/group, *P < 0.05).