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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Am J Nephrol. 2019 Dec 10;51(1):43–53. doi: 10.1159/000504869

Table 1:

Clinical Characteristics of 76 individuals who underwent next generation sequencing and kidney biopsy

Total Patients
(N=75)		 Patients with a
genetic
diagnosis
(N=39)		 Patient with no
genetic
diagnosis
(N=36)		 p value
Median age at biopsy, years (range) 36 (7–69) 33 (10–61) 38 (7–69) 0.11
Male sex 49 (65%) 26 (66%) 27 (75%) 0.3
Family history 69 (92%) 37 (95%) 32 (89%) 0.33
Histological diagnosis
  TIKD
  Glomerulonephritis
  FSGS/Alport
  TMA
  Non-specific features
18 (24%)
15 (20%)
11 (15%)
17 (23%)
14 (18%)
13 (33%)
4 (10%)
6 (15.5%)
10 (26%)
6 (15.5%)
5 (14%)
11(31%)
5 (14%)
7 (19%)
8 (22%)
Median creatinine at biopsy (Interquartile) (umol/L) 153 (101–208) 154 (99–201) 154 (112–258) 0.88
Developed end stage renal Disease 52 (69%) 28 (72%) 24 (66%) 0.63
Median time in years from initial biopsy and diagnosis to NGS (range) 15 (1–46) 17 (1–45) 15 (1–46) 0.24