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. 2019 Aug 22;9(2):195–218. doi: 10.1016/j.jcmgh.2019.08.004

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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TIL clusters correlate with tumor microenvironment. (A) Heatmap showing the normalized expression of the indicated markers for each CD4⁺ TIL cluster. The color scale indicates the relative expression levels. (B) Box plots showing the frequency of CD4⁺ TIL groups in inflamed tumors (immune-inflamed tumors) vs noninflamed tumors (immune-excluded and immune-desert tumors). (C) Heatmap showing the normalized expression of the markers for each CD8⁺ TIL cluster. The color scale indicates the relative expression levels. (D) Box plots showing the frequency of CD8⁺ TIL groups in inflamed tumors (immune-inflamed tumors) vs noninflamed tumors (immune-excluded and immune-desert tumors). (E) Heatmap showing the normalized expression of the markers for each DN TIL cluster. The color scale indicates the relative expression levels. (F) Box plots showing the frequency of DN TIL groups in inflamed tumors (immune-inflamed tumors) vs noninflamed tumors (immune-excluded and immune-desert tumors).