. 2019 Jan 12;10(1):26–35. doi: 10.1016/j.jtcme.2019.01.001

Table 1.

Therapeutic effect of naringenin against antituberculosis drugs induced alterations in liver and kidney function tests toxicity.

	AST	ALT	ALP	Urea	Uric acid	Creatinine
	(IU/L)	(IU/L)	(IU/L)	(mg/dl)	(mg/dl)	(mg/dl)
Control	72.2 ± 3.8	29.7 ± 2.5	292.0 ± 25.9	15.6 ± 1.4	1.86 ± 0.1	0.72 ± 0.1
Nar per se	74.4 ± 4.0	29.3 ± 2.4	304.0 ± 23.3	15.7 ± 1.5	1.95 ± 0.1	0.74 ± 0.1
ATD	116 ± 6.1^ф	71.8 ± 4.9^ф	558.0 ± 35.8^ф	32.3 ± 2.6^ф	4.46 ± 0.3^ф	1.81 ± 0.2^ф
ATD + Nar10	90.5 ± 4.9**	38.5 ± 3.1**	520.0 ± 45.3	20.3 ± 1.9**	3.18 ± 0.3**	0.91 ± 0.1**
ATD + Nar20	81.9 ± 5.5**	32.5 ± 1.9**	445.0 ± 35.1*	18.62 ± 1.8**	2.73 ± 0.1**	0.88 ± 0.1**
ATD + Nar40	76.1 ± 4.2**	31.2 ± 2.1**	368.0 ± 25.6**	17.1 ± 1.6**	2.62 ± 0.2**	0.82 ± 0.1**
ATD + Sily50	78.5 ± 5.1**	37.1 ± 2.9**	363.0 ± 29.1**	19.5 ± 1.1**	1.85 ± 0.1**	0.87 ± 0.1**
ANOVA	11.5^@	30.1^@	12.3^@	12.7^@	27.7^@	28.5^@

Data are mean ± S.E of n = 6; @ Significant at 5% for ANOVA.

^фATD vs Control at P ≤ 0.01,*ATD + Therapy vs ATD at P ≤ 0.05, **ATD + Therapy vs ATD at P ≤ 0.01.

ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; ALP, Alkaline phosphatase; ATD, Antituberculosis drugs; Nar per se, Naringenin per se, Nar10, Naringenin 10 mg/kg; Nar20, Naringenin 20 mg/kg; Nar40, Naringenin 40 mg/kg; Sily50, Silymarin 50 mg/kg.