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. 2019 Dec 18;19:572–580. doi: 10.1016/j.omtn.2019.12.007

Figure 4.

Figure 4

Small RNA Expression in Hearts of shRNA-Treated Mice

(A) MicroRNA levels in the hearts of 19-mer and 21-mer injected mice, as determined by deep sequencing. n = 3 mice per group, except for 21-nt, 12 weeks, for which n = 2 due to premature death of an animal. Data are mean ± SD. (B) Representative northern blots (of n = 3 biological replicates run three times) showing microRNA levels in the hearts of 19-mer and 21-mer injected mice in different biological replicates at 6 weeks post-injection. “MW” is a synthesized 21-nt RNA marker. AP, alkaline phosphatase.