Table 2.
Titration schedule and blood Phe during reintroduction of pegvaliase after pregnancy and breastfeeding in woman with PKU.
| Week | Pegvaliase dose (mg) | Frequency | Blood Phe (μmol/L) |
|---|---|---|---|
| 1 | 2.5 | 2× weekly | 1406 |
| 2 | 10 | 1× weekly | 1230 |
| 3 | 10 | 2× weekly | Not done |
| 4 | 10 | 4× weekly | 1484 |
| 5 | 10 | Daily | Not done |
| 6 | 20 | Daily | 648 |
| 7 | 20 | Daily | 30 |
| 8 | 20 | Daily | 36 |
| 11 | 20 | Daily | 109 |
| 12 | 20 | Daily | 309 |
| 14 | 20 | Daily | 370 |
| 19 | 20 | Daily | 48 |
| 21 | 20 | Daily | 170 |
| 23 | 30 | Daily | 246 |
| 25 | 30 | Mon, Wed, Fri | 6 |
| 20 | Sun, Tue, Thr, Sat | ||
| 27 | 30 | Mon, Wed, Fri | 0 |
| 20 | Sun, Tue, Thr, Sat | ||
| 32 | 30 | Mon, Wed, Fri | 18 |
| 20 | Sun, Tue, Thr, Sat | ||
| 33 | 30 | Mon, Wed, Fri | 36 |
| 20 | Sun, Tue, Thr, Sat |