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. 2019 Oct 24;9(2):257–276. doi: 10.1016/j.jcmgh.2019.10.007

Figure 4.

Figure 4

Biphasic kinetics of H pylori–induced changes in LATS2 and YAP1 expressions in cultured gastric and nongastric cells. (A) Relative mRNA levels for LATS2 and YAP1 assessed by RT-qPCR at 1, 2, 5, and 24 hours of HPI with H pylori 7.13 WT and ΔcagA strains in AGS, MKN74, RPE1, and HMLE cell lines. (B) Biphasic kinetics of TEAD-luciferase reporter activity with H pylori 7.13 WT and ΔcagA at 2, 5, and 24 hours of HPI. (C) Relative mRNA levels for the YAP1/TEAD target genes CTGF and CYR61, assessed by RT-qPCR, in kinetics of infection with H pylori 7.13 WT and ΔcagA strains. (A–C) Bars represent means ± SEM of fold changes relative to noninfected cells, 3 < n < 6. *P < .05, **P < .01, and ***P < .001 vs noninfected, using the Kruskal–Wallis test. $Unavailable data.