Figure 2.

Effect of HFD and hepatic ERα deficiency on body weight and food intake. A. Body weight (BW) of ERα^f/f and LERKO mice measured weekly along the 16 weeks long experiment and expressed as percentage versus time 0. B. BW of ERα^f/f and LERKO mice measured at the end of the 16 weeks long experiment. C. Quantification of the visceral white adipose tissue (vWAT) normalized over the BW. D. Feeding efficiency expressed as δBW/δFI (δBody weight/δFood intake). E. Food intake (FI) expressed as kcal %. Data are presented as mean ± SEM (n = 18). °p<0.05, °°p<0.01 and °°°p<0.001 LERKO vs ERα^f/f; #p<0.05, ##p<0.01 and ###p<0.001 HFD vs LFD (two-way ANOVA followed by Bonferroni’s post hoc test).