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. 2019 Oct 10;9(2):295–312. doi: 10.1016/j.jcmgh.2019.10.002

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

IKKβ(EE)-expressing intestinal crypts are highly susceptible to TNF-induced apoptosis independently of toll-like receptor signaling. (A) WT and Ikkβ(EE)^IEC mice were analyzed 4 hours after TNF injection (2 μg intravenously). Jejunal sections were stained with either H&E or antibodies to cC-3 or cC-8. Magnification bars: 100 μm. (B) Lysates of WT and Ikkβ(EE)^IEC intestinal mucosa were analyzed at different times after LPS injection (5 mg/kg) by IB. (C) Ikkβ(EE)^IEC and Ikkβ(EE)^IEC/Tnf^–/– mice were injected with TNF (2 μg intravenously). Jejunal sections were prepared 4 hours later and stained with antibodies to either cC-3 or cC-8. Magnification bars: 100 μm. (D) Ikkβ(EE)^IEC/Myd88^ΔIEC and Ikkβ(EE)^IEC/Myd88^F/F mice were analyzed 4 hours after TNF injection as above.