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Deletion of NKCC1 results in death in C57BL/6J. (A) NKCC1DFX/DFX mice in C57BL/6J and mixed C57BL/6J:DBA/2J background were maintained in a pathogen-free environment and survival was determined. The B6:D2 KO mice that survived the periweaning period lived for several months until use. (B) Gross anatomy of the cecum and colon of NKCC1WT/WT, NKCC1WT/DFX, and NKCC1DFX/DFX in C57BL/6J background around weaning time.
