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. 2019 Oct 23;9(2):239–255. doi: 10.1016/j.jcmgh.2019.10.006

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

NKCC1 is required for enteric C rodentium infection clearance. NKCC1^WT/WT, NKCC1^WT/DFX, and NKCC1^DFX/DFX mice were infected with 10⁹ colony forming units of a kanamycin-resistant strain of C rodentium. Feces were collected every day, eluted, plated, and bacteria were enumerated. (A) Percentage of NKCC1^WT/WT, NKCC1^WT/DFX, and NKCC1^DFX^/DFX mice with positive C rodentium shedding in feces over the 9-day period. (B) Bacteria plated on a kanamycin-containing plate show colonization or delay clearance in NKCC1^WT/DFX and NKCC1^DFX/DFX mice. (C) Inflammatory cytokine production in the serum of NKCC1^WT/WT, NKCC1^WT/DFX, and NKKCC1^DFX/DFX mice after 9 days postinfection (n = 3–5 mice per group, the experiment was repeated twice). hets, heterozygotes; homos, homozygotes; IL, interleukin; INF, interferon.