Table 8.
Pharmacokinetic results. Dose-level: 1 mg/animal.
| Analyte | Matrix | Rsq | No. of points used to calculate λz | λz | t1/2 (90% CI)* | Tmax | Cmax | C0 | AUC0–t | AUC0–∞ | AUCt–∞ extrapolated |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1/h | h | h | µg-eq/g | µg-eq/g | h*µg-eq/g | h*µg-eq/g | % | ||||
| HA | Knee | 0.957 | 3 | 0.0061 | 114 (101–131) | 6 | na | 736 | 21,223 | 21,647 | 2 |
| na | 2 | 0.0053 | 131 (77–441) | nc | nc | ||||||
| HA | Plasma | 0.995 | 4 | 0.0088 | 79 (57–130) | 24 | 7.47 | na | 989 | 1127 | 12 |
| na | 2 | 0.0054 | 129 (102–174) | nc | nc | ||||||
| CS | Knee | 0.989 | 3 | 0.0085 | 82 (69–99) | 6 | na | 80.9 | 4746 | 5051 | 6 |
| na | 2 | 0.0056 | 125 (67–845) | nc | nc | ||||||
| CS | Plasma | 0.971 | 4 | 0.0079 | 88 (74–109) | 1 | 4.90 | na | 39.8 | 40.8 | 3 |
| na | 2 | 0.0056 | 124 (87–218) | nc | nc |
CS = chondroitin sulfate; HA = hyaluronic acid; na = not applicable; nc = not calculated; Rsq = R-squared; λz = elimination time constant; t1/2 = half-life; CI = confidence interval; C0 = concentration at time zero (extrapolated); Cmax = maximal concentration; Tmax = time for maximal reading; AUC = area under the curve.
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Calculated using R version 3.6.1. (R Foundation for Statistical Computing, Vienna, Austria).