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. 2020 Jan 9;12:177–187. doi: 10.2147/CMAR.S232235

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© 2020 Qian et al.

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Identification of the potential miRNA sponged by circ-HIPK3. (A) Schematic representation of the potential binding sites of miR-338-3p with circ-HIPK3 (https://circinteractome.nia.nih.gov/) and the mutation sites for specific assay; (B), double luciferase reporter assay in the SiHa and C-4I cells co-tranfected with circ-HIPK3WT or mutated reporter with or without miR-338-3p mimics; (C), miR-338-3p in the CC cell lysates was pulled down and enriched with biotin-labeled miR-338-3p specific probe; (D) the miR-338-3p expression level in the human CC cells (HeLa, CaSki, SiHa, C-33A, C-4I, SW756) and the normal human cervical epithelial End1/E6E7 cells; (E), the miR-338-3p expression levels in paired CC and adjacent normal tissues from 45 CC patients (same samples as in Figure 1A) detected by qRT-PCR; (F) the miR-338-3p expression levels in circ-HIPK3-silenced SiHa and C-4I cells detected by qRT-PCR; (G) Pearson correlation analysis of the association between miR-338-3p with circ-HIPK3 in the CC tissues from the 45 CC patients (same samples as in Figure 1A). *p < 0.05; **p< 0.01, ***p< 0.001.