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. 2020 Jan 8;13:173–183. doi: 10.2147/OTT.S240113

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© 2020 Zhang et al.

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LINC00473 regulated radiosensitivity of HCC cells via miR-345-5p/FOXP1 axis. (A) The correlation between LINC00473 and FOXP1 expression in HCC tissues was confirmed by Spearman correlation analysis. (B–K) Huh-7 and SK-HEP-1 cells were introduced with si-NC, si-LINC00473#1, si-LINC00473#1+anti-miR-345-5p or si-LINC00473#1+FOXP1, respectively. (B, C) The mRNA level of FOXP1 was examined by qRT-PCR. (D, E) The protein level of FOXP1 was detected using Western blot analysis. (F, G) MTT assay was conducted to detect the viability of Huh-7 and SK-HEP-1 cells. (H, I) Colony survival assay was utilized to assess the radiosensitivity of Huh-7 and SK-HEP-1 cells after transfection. (J, K) Flow cytometry was used to evaluate cell viability after treatment with 6 Gy radiation for 24 h. *P < 0.05.