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. 2018 Jan 1;11(1):169–178.

Figure 2.

Figure 2

Gadd153 activities on inflammatory cells proliferation. Deficiency of Gadd153 reduced abdominal aortic aneurysm (AAA) lesion Mac-3+ macrophage-positive area (A) and CD4+ T-cell numbers (B) in the adventitia at 14 days post perfusion. In vitro cell proliferation assay showed that Gadd153 deficiency impaired CD4+ T-cell proliferation (C). In AAA lesion adventitia, numbers of Ki67-positive cells (D) and percentage of CD4+ T-cells among Ki67-positive cells (E; arrows indicate Ki67+; CD4+ T cells) were also reduced in Gadd153-/-mice at 14 days post perfusion. The number of mice per group is indicated in each bar. All data are mean ± SE. P < 0.05 is considered statistically significant; Mann-Whitney U test.