Table 2.
Bone Mineral Density, Bone Marrow Adipose Tissue, and Hormonal Parameters at Baseline and After 3 and 6 Months of Transdermal Estrogen
| Baseline(n = 11) | After 3 months of transdermal estrogen(n = 10) | After 6 months of transdermal estrogen(n = 8) | p value for 3 months versus baseline | p value for 6 months versus baseline | |
|---|---|---|---|---|---|
| BMD | |||||
| Lumbar spine (g/cm2) | 0.78 ± 0.03 | 0.79 ± 0.03 | 0.81 ± 0.04 | 0.072 | 0.033 |
| Lateral spine (g/cm2) | 0.60 ± 0.03 | 0.63 ± 0.03 | 0.64 ± 0.03 | 0.104 | 0.015 |
| Total hip (g/cm2) | 0.74 ± 0.03 | Not measured | 0.73 ± 0.04 | – | 0.197 |
| Femoral neck (g/cm2) | 0.64 ± 0.02 | Not measured | 0.65 ± 0.03 | – | 0.181 |
| Bone marrow adipose tissue | |||||
| L4 vertebra (lipid/water) | 1.05 ± 0.12 | 0.93 ± 0.11 | 0.98 ± 0.12 | 0.046 | 0.124 |
| Femoral metaphysis (lipid/water) | 5.47 [3.44, 7.87] | 4.45 [2.35, 7.69] | 4.28 [3.74, 6.04] | 0.131 | 0.383 |
| Femoral diaphysis (lipid/water) | 7.28 ± 0.73 | 7.42 ± 1.10 | 7.71 ± 0.86 | 0.843 | 0.657 |
| Femoral epiphysis (lipid/water) | 7.43 ± 0.79 | 6.85 ± 0.97 | 7.80 ± 0.75 | 0.365 | 0.722 |
| Hormonal parameters | |||||
| IGF‐1 (ng/mL) | 150 [140, 160] | 147 [138, 159] | 149 [133, 174] | 0.557 | 0.813 |
| P1NP (ng/mL) | 49.5 [35.9, 71.1] | 58.2 [36.2, 82.2] | 56.0 [42.8, 60.5] | 0.695 | 0.469 |
| Osteocalcin (ng/mL) | 11.7 [7.2, 31.4] | 12.2 [8.1, 31.9] | 13.8 [8.6, 32.8] | 0.770 | 0.469 |
| CTX (ng/mL) | 0.51 ± 0.09 | 0.39 ± 0.07 | 0.38 ± 0.09 | 0.003 | 0.005 |
| Sclerostin (pg/mL) | 91.7 ± 4.8 | 71.5 ± 3.8 | 84.5 ± 10.3 | 0.011 | 0.985 |
Mean ± SEM or median [interquartile range] when data were not normally distributed. p values <0.05 are in boldface.
CTX = C‐terminal collagen cross‐links.