Table 3.

Univariate Associations Between Changes in Biologically Plausible Hormonal Parameters and Changes in BMD and Bone Marrow Adipose Tissue in Response to Transdermal Estrogen (Spearman's Rho)

	3‐Month change in CTX	6‐Month change in CTX	3‐Month change in P1NP	6‐Month change in P1NP	3‐Month change in osteocalcin	6‐Month change in osteocalcin	3‐Month change in sclerostin	6‐Month change in sclerostin	3‐Month change in IGF‐1	6‐Month change in IGF‐1
3‐Month change in BMD
Lumbar spine	rho = 0.25	Not assessed	rho = 0.27	Not assessed	= −0.01	Not assessed	rho = −0.44	Not assessed	rho = 0.67	Not assessed
	p = 0.489		p = 0.446		p = 0.987		p = 0.200		p = 0.033
Lateral spine	rho = −0.21	Not assessed	rho = 0.30	Not assessed	rho = 0.24	Not assessed	rho = −0.67	Not assessed	rho = 0.44	Not assessed
	p = 0.556		p = 0.405		p = 0.511		p = 0.033		p = 0.200
6‐Month change in BMD
Lumbar spine	rho = −0.36	rho = −0.18	rho = 0.14	rho = 0.18	rho = 0.14	rho = −0.07	rho = 0.21	rho = −0.21	rho = −0.24	rho = 0.04
	p = 0.385	p = 0.702	p = 0.736	p = 0.702	p = 0.736	p = 0.879	p = 0.610	p = 0.645	p = 0.570	p = 0.939
Lateral spine	rho = −0.71	rho = 0.36	rho = 0.29	rho = 0.75	rho = −0.19	rho = 0.57	rho = −0.62	rho = −0.82	rho = 0.29	rho = 0.79
	p = 0.047	p = 0.432	p = 0.493	p =0.052	p = 0.651	p = 0.180	p = 0.102	p = 0.023	p = 0.493	p = 0.036
3‐Month change in bone marrow adiposity
L4 vertebra	rho = −0.27	rho = −0.54	rho = 0.18	rho = −0.49	rho = −0.10	rho = −0.71	rho = −0.15	rho = −0.43	rho = 0.30	rho = −0.14
	p = 0.488	p = 0.266	p = .0.637	p = 0.329	p =0.798	p = 0.111	p = 0.700	p = 0.397	p = 0.433	p = 0.787
Femoral metaphysis	rho = −0.60	rho = −0.36	rho = 0.09	rho = 0.25	rho = 0.43	rho = −0.14	rho = −0.36	rho = −0.36	rho = 0.32	rho = −0.07
	p = 0.067	p = 0.432	p = 0.803	p = 0.589	p = 0.215	p =0.760	p = 0.310	p = 0.432	p = 0.366	p = 0.879
Femoral diaphysis	rho = −0.42	rho = −0.82	rho = 0.47	rho = −0.11	rho = 0.35	rho = −0.50	rho = −0.20	rho = −0.39	rho = 0.25	rho = −0.18
	p = 0.229	p = 0.023	p = 0.174	p = 0.819	p = 0.328	p = 0.253	p = 0.580	p = 0.383	p = 0.489	p = 0.702
Femoral epiphysis	rho = −0.30	rho = −0.77	rho = 0.17	rho = −0.54	rho = 0.18	rho = −0.89	rho = 0.13	rho = 0.20	rho = 0.13	rho = −0.77
	p = 0.433	p = 0.072	p = 0.668	p = 0.266	p = 0.637	p = 0.019	p = 0.732	p = 0.704	p = 0.732	p = 0.072
6‐month change in bone marrow adiposity
L4 vertebra	rho = −0.50	rho = 0.37	rho = −0.04	rho = 0.09	rho = −0.71	rho = 0.03	rho = −0.68	rho = −0.43	rho = 0.71	rho = 0.37
	p = 0.253	p = 0.469	p = 0.939	p = 0.872	p = 0.071	p = 0.957	p = 0.094	p = 0.397	p = 0.071	p = 0.469
Femoral metaphysis	rho = −0.67	rho = −0.14	rho = −0.31	rho = 0.36	rho = 0.43	rho = 0.07	rho = −0.26	rho = −0.14	rho = −0.14	rho = −0.11
	p = 0.071	p = .760	p = 0.456	p = 0.432	p = 0.289	p = 0.879	p = 0.531	p = 0.760	p = 0.736	p = 0.819
Femoral diaphysis	rho = 0.14	rho = −0.43	rho = 0.36	rho = −0.11	rho = 0.02	rho = −0.21	rho = −0.05	rho = −0.46	rho = −0.50	rho = 0.14
	p = 0.736	p = 0.337	p = 0.385	p = 0.819	p = 0.955	p = 0.645	p = .0.911	p = 0.294	p = 0.207	p = 0.760
Femoral epiphysis	rho = −0.14	rho = −0.20	rho = −0.14	rho = −0.54	rho = −0.79	rho = −0.54	rho = 0.21	rho = −0.14	rho = −0.50	rho = −0.09
	p = 0.760	p = 0.704	p = 0.760	p = 0.266	p = 0.036	p = 0.266	p = 0.645	p = 0.787	p = 0.253	p = 0.872

p values <0.05 are in boldface.

CTX = C‐terminal collagen cross‐links.