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Decreased CDKL2 protein nuclear expression was examined in glioma tissues compared to non-cancerous brain samples (original magnifications are:×200). A: Positive nuclear expression of CDKL2 in non-cancerous brain tissues. B: CDKL2 positive nuclear expression in the glioma tissues. C: High CDKL2 expression in cytoplasm of glioma tissues, but low expression in nuclei. D: Negative expression of CDKL2 in glioma tissues. (insets displaying cdkl2 expression under high magnification ×400).
