Table 2.
Univariate and multivariate analyses of RFS
| Parameters | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| HR | 95% CI | p | HR | 95% CI | p | |
| Gender | ||||||
| Female vs. Male | 0.860 | 0.546-1.353 | 0.514 | |||
| Age (years) | ||||||
| ≥60 years vs. <60 years | 1.303 | 0.831-2.044 | 0.249 | |||
| Location of tumor | ||||||
| The distal 1/2 vs. The proximal 1/2 | 0.850 | 0.511-1.415 | 0.533 | |||
| Preoperative CEA (ng/ml) | ||||||
| ≥5 ng/ml vs. <5 ng/ml | 1.593 | 0.986-2.573 | 0.057 | |||
| Tumor size (cm) | ||||||
| ≥5 cm vs. <5 cm | 2.486 | 1.566-3.948 | <0.001 | 1.108 | 0.654-1.877 | 0.704 |
| Clinical stage | ||||||
| III-IV vs. I-II | 5.821 | 3.287-10.309 | <0.001 | 2.628 | 1.223-5.646 | 0.013 |
| Depth of invasion | ||||||
| T3-T4 vs. T1-T2 | 5.001 | 2.763-9.050 | <0.001 | 2.860 | 1.335-6.127 | 0.007 |
| Lymph node status | ||||||
| N2-N3 vs. N0-N1 | 2.921 | 1.840-4.639 | <0.001 | 2.113 | 1.218-3.668 | 0.008 |
| Histological grade | ||||||
| Poor vs. Well + Moderately | 1.966 | 1.213-3.186 | 0.006 | 1.834 | 1.046-3.217 | 0.034 |
| Nerve invasion | ||||||
| Yes vs. No | 1.249 | 0.795-1.961 | 0.335 | |||
| Vascular invasion | ||||||
| Yes vs. No | 2.709 | 1.725-4.255 | <0.001 | 1.842 | 1.132-2.999 | 0.014 |
| SCUBE2 expression | ||||||
| Low vs. High | 2.468 | 1.535-3.969 | <0.001 | 1.746 | 1.060-2.875 | 0.029 |
HR hazard ratio, CI confidence interval. Bold numbersindicate statistical significance, P<0.05.