Table 3.
Bioinformatics analysis of the proteomic results
| KEGG Pathways | ||||
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| Pathway ID | Pathway description | Observed gene count | False discovery rate | Matching proteins in your network (labels) |
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| 4610 | Complement and coagulation cascades | 9 | 1.02E-08 | C4B, CPB2, FGA, FGB, FGG, KNG1, MBL2, SERPINC1, VWF |
| 1230 | Biosynthesis of amino acids | 7 | 4.18E-06 | ACO2, ALDOA, ALDOC, ENO2, GLUL, PKM, TPI1 |
| 4114 | Oocyte meiosis | 8 | 4.18E-06 | CALM1, CAMK2A, CAMK2B, PPP3CC, YWHAE, YWHAG, YWHAQ, YWHAZ |
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| Biological Process (GO) | ||||
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| Pathway ID | Pathway description | Observed gene count | False discovery rate | Matching proteins in your network (labels) |
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| GO: 0002576 | Platelet degranulation | 13 | 2.36E-12 | ALDOA, CALM1, FGA, FGB, FGG, KNG1, PF4, PFN1, PPIA, TLN1, TMSB4X, TUBA4A, VWF |
| GO: 0030168 | Platelet activation | 17 | 3.05E-12 | ALDOA, CALM1, FGA, FGB, FGG, GNB1, GP5, KNG1, PF4, PFN1, PPIA, SAA1, TLN1, TMSB4X, TUBA4A, VWF, YWHAZ |
| GO: 0065008 | Regulation of biological quality | 46 | 3.05E-12 | ALDOA, APCS, APOC4, ATP1A3, ATP6V1A, AZGP1, CALM1, CAMK2A, CAMK2B, CD44, CKB, CPB2, DPYSL2, FGA, FGB, FGG, GFAP, GLUL, GP5, HIST1H4A, HSP90AB1, HSPA8, KNG1, LPA, MBL2, MUC2, PF4, PFN1, PHB, PIGR, PPIA, PRKAA1, S100B, SAA1, SELL, SEMA3F, SERPINC1, SLC25A6, SPTAN1, SPTBN1, TLN1, TUBA4A, VWF, YWHAE, YWHAG, YWHAZ |
| GO: 0009611 | Response to wounding | 25 | 7.82E-12 | ALDOA, APOD, CALM1, CPB2, FGA, FGB, FGG, GFAP, GNB1, GP5, KNG1, LPA, PF4, PFN1, PKM, PPIA, SAA1, SELL, SERPINC1, SRSF5, TLN1, TMSB4X, TUBA4A, VWF, YWHAZ |
| GO: 0007596 | Blood coagulation | 21 | 4.52E-11 | ALDOA, CALM1, CD44, CPB2, FGA, FGB, FGG, GNB1, GP5, KNG1, PF4, PFN1, PPIA, SAA1, SELL, SERPINC1, TLN1, TMSB4X, TUBA4A, VWF, YWHAZ |
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| Molecular Function (GO) | ||||
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| Pathway ID | Pathway description | Observed gene count | False discovery rate | Matching proteins in your network (labels) |
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| GO: 0005515 | Protein binding | 53 | 2.07E-09 | ABCB9, ADAMTSL4, ALDOA, ALDOC, APCS, ATP1A3, ATP5A1, AZGP1, CALM1, CAMK2A, CAMK2B, CD44, CHGB, CKB, CLTC, COTL1, FGB, FGG, GLUL, GMNN, GNB1, HBB, HIST1H4A, HSP90AB1, HSPA8, HSPE1, HSPG2, KNG1, LPA, MBL2, MDN1, NCAM1, PF4, PFN1, PHB, PKM, PPIA, RAB10, S100B, SAA1, SELL, SERPINC1, SPTAN1, SPTBN1, TLN1, TPI1, UBA52, VCP, VWF, YWHAE, YWHAG, YWHAQ, YWHAZ |
| GO: 0005200 | Structural constituent of cytoskeleton | 9 | 1.90E-06 | GFAP, INA, SPTAN1, SPTBN1, TLN1, TUBA1A, TUBA4A, TUBB2A, TUBB3 |
| GO: 0005198 | Structural molecule activity | 15 | 7.19E-05 | CLTC, FGA, FGB, FGG, GFAP, INA, MBP, SPTAN1, SPTBN1, TLN1, TPM4, TUBA1A, TUBA4A, TUBB2A, TUBB3 |
| GO: 0097367 | Carbohydrate derivative binding | 29 | 9.76E-05 | ABCB9, ATP1A3, ATP5A1, ATP6V1A, AZGP1, CAMK2A, CAMK2B, CD44, CKB, GLUL, HSP90AB1, HSPA8, HSPE1, KNG1, LPA, MDN1, PF4, PKM, PRKAA1, RAB10, SAA1, SELL, SERPINC1, TUBA1A, TUBA4A, TUBB2A, TUBB3, VCP, VWF |
| GO: 0023026 | MHC class II protein complex binding | 4 | 0.000131 | HSP90AB1, HSPA8, PKM, YWHAE |
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| Cellular Component (GO) | ||||
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| Pathway ID | Pathway description | Observed gene count | False discovery rate | Matching proteins in your network (labels) |
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| GO. 0044421 | Extracellular region part | 69 | 1.93E-28 | ADAMTSL4, ALDOA, ALDOC, APCS, APOC1, APOC4, APOD, ATP1A3, ATP5A1, ATP6V1A, AZGP1, CALM1, CD44, CKB, CLTC, COTL1, CPB2, DPYSL2, ENO2, FCGBP, FGA, FGB, FGG, GLUL, GNB1, GP5, HBA1, HGFAC, HIST1H4A, HPCAL1, HSP90AB1, HSPA8, HSPE1, INA, KNG1, LDHC, LGALS3BP, LPA, MBL2, MUC2, NCAM1, ORM1, PF4, PFN1, PHB, PIGR, PKM, PPIA, PPP3CC, RAB10, S100B, SAA1, SEMA3F, SERPINC1, SHBG, SPTAN1, SPTBN1, TLN1, TPM3, TUBA1A, TUBA4A, TUBB2A, TUBB3, VCP, VWF, YWHAE, YWHAG, YWHAQ, YWHAZ |
| GO. 1903561 | Extracellular vesicle | 61 | 1.82E-27 | ALDOA, ALDOC, APCS, APOC1, APOD, ATP1A3, ATP5A1, ATP6V1A, AZGP1, CALM1, CD44, CKB, CLTC, COTL1, CPB2, DPYSL2, ENO2, FCGBP, FGA, FGB, FGG, GLUL, GNB1, GP5, HBA1, HIST1H4A, HPCAL1, HSP90AB1, HSPA8, HSPE1, HSPG2, KNG1, LDHC, LGALS3BP, NCAM1, ORM1, PFN1, PHB, PIGR, PKM, PPIA, PPP3CC, RAB10, SAA1, SEPP1, SERPINC1, SHBG, SPTAN1, SPTBN1, TLN1, TPM3, TUBA1A, TUBA4A, TUBB2A, TUBB3, VCP, VWF, YWHAE, YWHAG, YWHAQ, YWHAZ |
| GO. 0005576 | Extracellular region | 72 | 2.11E-27 | ADAMTSL4, ALDOA, ALDOC, APCS, APOC1, APOC4, APOD, APOL3, ATP1A3, ATP5A1, ATP6V1A, AZGP1, CALM1, CD44, CFHR4, CHGB, CKB, CLTC, COTL1, CPB2, DPYSL2, ENO2, FCGBP, FGA, FGB, FGG, GLUL, GNB1, GP5, HBA1, HIST1H4A, HPCAL1, HSP90AB1, HSPA8, HSPE1, INA, KNG1, LDHC, LGALS3BP, LPA, MBL2, MUC2, NCAM1, ORM1, PF4, PFN1, PHB, PIGR, PKM, PPIA, PPP3CC, RAB10, SAA1, SEMA3F, SERPINC1, SHBG, SPTAN1, SPTBN1, TLN1, TMSB4X, TPM3, TUBA1A, TUBA4A, TUBB2A, TUBB3, VCP, VWF, WFDC11, YWHAE, YWHAG, YWHAQ, YWHAZ |
| GO. 0070062 | Extracellular exosome | 60 | 8.03E-27 | ALDOA, ALDOC, APCS, APOC1, APOD, ATP5A1, ATP6V1A, AZGP1, CALM1, CD44, CKB, CLTC, COTL1, CPB2, DPYSL2, ENO2, FCGBP, FGA, FGB, FGG, GLUL, GNB1, GP5, HBA1, HIST1H4A, HPCAL1, HSP90AB1, HSPA8, HSPE1, HSPG2, KNG1, LDHC, LGALS3BP, NCAM1, ORM1, PFN1, PHB, PIGR, PKM, PPIA, PPP3CC, RAB10, SAA1, SEPP1, SERPINC1, SHBG, SPTAN1, SPTBN1, TLN1, TPM3, TUBA1A, TUBA4A, TUBB2A, TUBB3, VCP, VWF, YWHAE, YWHAG, YWHAQ, YWHAZ |
| GO. 0031988 | Membrane-bounded vesicle | 64 | 7.84E-26 | ALDOA, ALDOC, APCS, APOC1, APOD, ATP5A1, ATP6V1A, AZGP1, CALM1, CAMK2A, CAMK2B, CD44, CHGB, CKB, COTL1, CPB2, DPYSL2, ENO2, FCGBP, FGA, FGB, FGG, GLUL, GNB1, GP5, HBA1, HIST1H4A, HPCAL1, HSP90AB1, HSPA8, HSPE1, HSPG2, KNG1, LDHC, LGALS3BP, NCAM1, ORM1, PF4, PFN1, PHB, PIGR, PKM, PPIA, PPP3CC, RAB10, SAA1, SEPP1, SERPINC1, SHBG, SPTAN1, SPTBN1, TLN1, TMSB4X, TPM3, TUBA1A, TUBA4A, TUBB2A, TUBB3, VCP, VWF, YWHAE, YWHAG, YWHAQ, YWHAZ |