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. 2018 Mar 1;11(3):1247–1255.

Figure 1.

Figure 1

Activation of the HIF-1α/Profilin-1 pathway under HG conditions in vivo and in vitro. (A-C) Western blotting (A) and quantification (B) of HIF-1α and Profilin-1 protein or real-time RT-PCR analysis of mRNA (C) expression profiles in the following cell treatment groups: NG, HG for 48 h (HG 48 h), and HG 72 h. **P<0.01 vs. NG; ##P<0.01 vs. HG. (D-F) Western blotting (D) and quantification (E) of HIF-1α and Profilin-1 protein or real-time RT-PCR analysis of mRNA (F) expression profiles in the control rat group (Con), diabetic rat group (DM), and DM plus metformin group (DM + Met). **P<0.01 vs. Con; ##P<0.01 vs. DM. Means ± SD. n=3.