Table 2.
Association between miRNA SNPs and presence of diabetes mellitus and diabetic nephropathy
| SNP (gene) | Genotypes/allele | CON number (%) | DM number (%) | DN number (%) | DM vs CON | DN vs CON | ||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| P | P a | ORa (95% CI) | P | P a | ORa (95% CI) | |||||
| rs12128240 | CC | 74 (63.2) | 86 (66.2) | 18 (60) | 0.633 | - | 0.743 | - | ||
| CT | 40 (34.2) | 39 (30) | 10 (33.3) | 0.481 | 0.226 | 0.665 (0.344-1.287) | 0.930 | 0.068 | 0.035 (0.001-1.286) | |
| TT | 3 (2.6) | 5 (3.8) | 2 (6.7) | 0.725 | 0.630 | 1.560 (0.256-9.487) | 0.269 | 0.063 | 0.034 (0.001-1.205) | |
| T | 46 (19.7) | 49 (18.8) | 14 (23.3) | 0.819 | 0.437 | 0.642 (0.210-1.964) | 0.529 | 0.426 | 1.550 (0.526-4.564) | |
| rs6577555 | AA | 12 (10.3) | 14 (10.8) | 3 (10) | 0.896 | - | 0.967 | - | ||
| AC | 42 (35.9) | 46 (35.4) | 9 (30) | 0.933 | 0.520 | 0.519 (0.071-3.814) | 0.545 | 0.508 | 0.520 (0.075-3.617) | |
| CC | 63 (53.8) | 70 (53.8) | 18 (60) | 1 | 0.695 | 0.685 (0.103-4.551) | 0.545 | 0.959 | 1.047 (0.177-6.214) | |
| C | 168 (71.8) | 186 (71.5) | 45 (75) | 0.950 | 0.858 | 0.917 (0.355-2.369) | 0.620 | 0.288 | 0.023 (0.000-23.916) | |
| rs2666433 | AA | 5 (4.3) | 12 (9.2) | 2 (6.7) | 0.124 | - | 0.583 | - | ||
| AG | 43 (36.7) | 63 (48.5) | 8 (26.7) | 0.063 | 0.940 | 0.902 (0.062-13.114) | 0.301 | 0.991 | 1.015 (0.086-12.047) | |
| GG | 69 (59.0) | 55 (42.3) | 20 (66.6) | <0.05 | 0.484 | 0.381 (0.026-5.679) | 0.442 | 0.642 | 0.704 (0.161-3.086) | |
| G | 181 (78.4) | 173 (66.5) | 48 (80) | <0.05 | 0.274 | 0.586 (0.225-1.527) | 0.659 | 0.778 | 0.852 (0.279-2.601) | |
a
ORs and P-values were adjusted for age, FBG, 2 h PG in a logistic regression model.