Table 3.
Effects of H19 on the weight and volume and tumor growth inhibition rates of xenografts in four kinds of nude mice
| Mean ± standard deviation | F value | P value | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Group 1 | Group 2 | Group 3 | Group 4 | |||
| Weight | 1.057 (0.316) | 1.131 (0.122) | 1.342 (0.142) | 0.755 (0.207) | 8.94 | 0.0062 |
| Volume | 1182.703 (303.625) | 1044.913 (205.760) | 1503.243 (248.010) | 786.933 (218.649) | 4.38 | 0.0421 |
| Inhibition rate | 0.000 (0.000) | 4.040 (1.085) | -29.283 (2.075) | 29.233 (4.550) | 263.41 | < 0.001 |
Xenografts of A375/H19+ cells were significantly larger than those of A375, A375/GFP, and A375/H19- cells in weight (P = 0.0062) and volume (P = 0.0421). Furthermore, xenografts of A375/H19+ cells were significantly smaller than those of A375, A375/GFP, and A375/H19- cells with regard to tumor growth inhibition rates (P < 0.001).