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SIRT6 is a direct target of miR-34a. A. Sequence alignment between miR-34a and the 3’-UTR of the human SIRT6 mRNA seed-matching region or seed-mutated region. B. Relative luciferase activity was calculated as follows: (Rluc miRNA/Luc miRNA)/(Rluc no-target/Luc nontarget). The data are presented as the average of triplicate values.
