Table 3.

The top 26 differentially expressed proteins in the fetal heart tissues of the sheep exposed to hypoxia

Differentially expression	Gene name	Severe/Mild		Mild/Normal		Severe/Normal
		Ratio	T test	Ratio	T test	Ratio	T test
Upregulated	SURF1	2.27440	0.00945	1.01100	0.59218	2.29941	0.03539
	PHYH	1.83916	0.24122	1.37521	0.03986	2.52923	0.25186
	CCS	1.63985	0.00244	1.01762	0.71198	1.66875	0.01432
	SKOR2	1.51264	0.00355	1.18486	0.02225	1.79226	0.00717
	REN	1.50684	0.00018	1.27150	0.03053	1.91595	0.00071
	W5Q9A6	1.50557	0.01366	1.18016	0.21017	1.77681	0.01248
	TSPAN17	1.43757	0.00854	1.03390	0.58952	1.48630	0.02273
	ACTR1B	1.41908	0.01250	1.16014	0.31777	1.64633	0.04005
	GUCY2F	1.38522	0.02842	1.06556	0.55657	1.47604	0.04131
	LOC101115423	1.37638	0.56495	1.36951	0.03605	1.88497	0.46592
	DSCR3	1.36059	0.01065	1.03826	0.52394	1.41265	0.02394
	IGHM	1.35870	0.00482	1.18352	0.00974	1.60804	0.00742
	APOBEC3F	1.31595	0.00027	1.09504	0.00418	1.44101	0.00132
	GPD1L	1.30613	0.00213	1.06665	0.06008	1.39319	0.00756
Downregulated	RTN3	0.75898	0.01218	0.98075	0.49804	0.74437	0.03207
	SCN3B	0.75803	0.00146	0.95341	0.01356	0.72272	0.00497
	EXOC8	0.74039	0.01855	0.91427	0.25967	0.67692	0.02973
	PGK2	0.72730	0.05809	0.73456	0.01284	0.53424	0.01367
	TNFAIP8	0.72274	0.04213	0.78152	0.07815	0.56483	0.04068
	ACOT4	0.68085	0.01129	0.99989	0.99896	0.68078	0.04264
	CPED1	0.67732	0.33791	0.51392	0.01448	0.34809	0.05065
	TMEM14C	0.63955	0.00131	0.91158	0.15693	0.58300	0.00233
	MPDZ	0.54306	0.15814	0.91208	0.80293	0.49531	0.02003
	COL28A1	0.45984	0.02078	0.86182	0.40641	0.39630	0.04065
	TTN	0.31632	0.00011	0.57689	0.00197	0.18248	0.00016
	HBB	0.09148	0.00007	0.95938	0.60434	0.08776	0.00012

NOTE: The genes in bold font met the criterion that Severe/Mild T test P < 0.05, and Mild/Normal Ration > 1.3 or Mild/Normal T test P < 0.05.