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LOXL1 regulates Wnt/β-catenin signaling in glioma cell lines. (A, B) Dual luciferase reporter assays revealed that depletion of LOXL1 significantly inhibits Wnt/β-catenin signaling in U87MG (A) and U251 (B) cells. (C) Silencing LOXL1 significantly inhibits the nuclear β-catenin level in U87MG and U251 cells. (D) β-catenin inhibitor IWR-1-endo rescues the promotive effects in NHA cell overexpression cell lines.
