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NF-κB p65 is involved in sunitinib resistance. (A) Western blotting analysis of NF-κB p65 expression and (B) NF-κB activity assay in sunitinib-sensitive or resistant RCC cell lines with PPARα overexpression or shRNA-mediated knockdown of PPARα. Cells were cultured with WY14643 or SN50 NF-κB inhibitors at 25 µM for 24 h. GADPH was used as loading control. *P < 0.05, **P < 0.01. PPARα-OE, PPARα overexpression.
